Abstract
Virus-induced disease occurs both through direct destruction of cells by viruses and/or secondarily through lysis of infected cells by immunological assault1–5. We asked whether viruses could also cause injury and disease by altering the cell's normal or expected functions without destroying the cells. Here we show that a relatively noncytopathic virus can perturb endocrine functions by disordering the synthesis of a hormone needed for growth and glucose regulation, while replicating in a specialized cell making that hormone. Yet, despite viral replication and alteration in synthesis of the specialized cell's homeostatic product, the infected cell remains free from structural injury.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fenner, F., McAuslan, B., Mims, C., Sambrook, J. & White, D. The Biology of Animal Viruses, 2nd edn (Academic, New York, 1974).
Notkins, A. (ed.) Viral Immunology and Immunopathology (Academic, New York, 1975).
Bablanian, R. Prog. med. Virol. 19, 40–83, 1975.
Blackwood, W. & Cornsellis, J. (eds) Neuropathology (Edward Arnold, London, 1976).
Robbins, S., Angell, M. & Kumar, V. Basic Pathology (Saunders, Philadelphia, 1981).
Doyle, L. B., Doyle, M. V. & Oldstone, M. B. A. Immunology 40, 589–596 (1980).
Rodriguez, M., von Wedel, R. J., Garrett, R. S., Lampert, P. W. & Oldstone, M. B. A. Lab. Invest. (in the press).
Oldstone, M. B. A. et al. Science 218, 1125–1127 (1982).
Buchmeier, M. J., Lewicki, H. A., Tomori, O. & Oldstone, M. B. A. Virology 113, 73–85 (1981).
Oldstone, M. B. A. & Buchmeier, M. J. Nature 300, 360–362 (1982).
Guyton, A. Textbook of Medical Physiology, 6th edn (Saunders, Philadelphia, (1981).
Bondy, P. & Rosenberg, L. Metabolic Control and Disease, 8th edn (Saunders, Philadelphia, 1980).
Rinderknecht, E. & Humbel, R. J. biol. Chem. 253, 2769–2776 (1978).
Daughaday, W., Parker, K., Borowsky, S., Trevedi, B. & Kapadia, M. Endocrinology 110, 575–581 (1982).
Tashjian, A., Yasumura, Y., Levine, L., Sato, G. & Parker, M. Endocrinology 82, 342–352 (1968).
Gresser, I., Morel-Maroger, L., Maury, C., Tovey, M. & Pontillon, F. Nature 263, 420–422 (1976).
Gresser, I., Morel-Maroger, L., Verroust, P., Riviere, Y. & Guillon, J. Proc. natn. Acad. Sci. U.S.A. 75, 3413–3916 (1978).
Riviere, Y. et al. J. exp. Med. 152, 663–640 (1980).
Dutko, F. J. & Oldstone, M. B. A. J. gen. Virol. (in the press).
Notkins, A. L. Scient. Am. 241, 62–73 (1979).
Onodera, T. et al. J. exp. Med. 153, 1451–1473 (1981).
Sinha, Y., Lewis, J. & Vanderlaan, W. J. Endocr. 55, 1–9 (1972).
Sinha, Y., Selby, F., Lewis, U. & Vanderlaan, W. Endocrinology 91, 784–792 (1972).
Onodera, T., Jenson, A., Yoon, J. & Notkins, A. Science 201, 529–531 (1978).
Buchmeier, M. J., Welsh, R. M., Dutko, F. J. & Oldstone, M. B. A. Adv. Immun. 30, 275–331 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Oldstone, M., Rodriguez, M., Daughaday, W. et al. Viral perturbation of endocrine function: disordered cell function leads to disturbed homeostasis and disease. Nature 307, 278–281 (1984). https://doi.org/10.1038/307278a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/307278a0
This article is cited by
-
The game's afoot: seeking viruses that cause chronic and degenerative neurologic and psychiatric disorder
Molecular Psychiatry (2012)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.