Abstract
A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa / Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.
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References
Scott, M. R. D., Westphal, K-H. & Rigby, P. W. J. Cell 34, 557–567 (1983).
Rigby, P. W. J. et al. in Genetic Manipulation: Impact on Man and Society (eds Starlinger, P. & Illmensee, K. ) (ICSU Press, Miami, in the press).
Lalanne, J. L. et al. Nucleic Acids Res. 10, 1039–1049 (1982).
Reyes, A. A., Schold, M., Itakura, K. & Wallace, R. B. Proc. natn. Acad. Sci. U.S.A. 79, 3270–3274 (1982).
Weiss, E. et al. EMBO J. 2, 453–462 (1983).
Reyes, A. A., Schold, M. & Wallace, R. B. Immunogenetics 16, 1–9 (1982).
Moore, K. W., Sher, B. T., Sun, Y. H., Eakle, K. A. & Hood, L. Science 215, 679–682 (1982).
Margulies, D. H. et al. J. Immun. 130, 463–470 (1983).
Steinmetz, M. et al. Cell 25, 683–692 (1981).
Krayev, A. S. et al. Nucleic Acids Res. 10, 7461–7475 (1982).
Kramerov, D. A., Lekakh, I. V., Samarina, O. P. & Ryskov, A. P. Nucleic Acids Res. 10, 7477–7491 (1982).
Parnes, J. R., Robinson, R. R. & Seidman, J. G. Nature 302, 449–452 (1983).
Parnes, J. R. & Seidman, J. G. Cell 29, 661–669 (1982).
Kress, M., Cosman, D., Khoury, G. & Jay, G. Cell 34, 189–196 (1983).
Murphy, D., Brickell, P. M., Latchman, D. S., Willison, K. & Rigby, P. W. J. Cell 35, 865–871 (1983).
Morello, D. et al. Nature 296, 260–262 (1982).
Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 78, 5754–5758 (1981).
Artzt, K. & Jacob, F. Transplantation 17, 632–634 (1974).
Jacob, F. Immun. Rev. 33, 3–32 (1977).
Stern, P., Martin, G. R. & Evans, M. J. Cell 6, 455–465 (1975).
Winoto, A., Steinmetz, M. & Hood, L. Proc. natn. Acad. Sci. U.S.A. 80, 3425–3429 (1983).
Michaelson, J. et al. Transplant Proc. (in the press).
Klein, J., Figueroa, F. & David, C. S. Immunogenetics 17, 553–596 (1983).
Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).
Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 55–177 (1979).
Klein, J., Juretic, A., Baxevanis, C. N. & Nagy, Z. A. Nature 291, 455–460 (1981).
Avner, P. R. et al. Immunogenetics 7, 103–115 (1978).
Johnson, L. L. et al. Immunogenetics 18, 137–145 (1983).
Levine, A. J. & Teresky, A. K. Immunogenetics 13, 405–412 (1981).
Ostrand-Rosenberg, S., Rider, T.M. & Twarowski, A. Immunogenetics 10, 607–612 (1980).
Shedlovsky, A., Clipson, L. J., Vandeberg, J. C. & Dove, W. F. Immunogenetics 13, 413–419 (1981).
Siegler, E. L., Tick, N., Teresky, A. K., Rosenstraus, M. & Levine, A. J. Immunogenetics 9, 207–220 (1979).
Stern, P. L., Gidlund, M., Orn, A. & Wigzell, H. Nature 285, 341–342 (1980).
Levine, A. J. Adv. Cancer Res. 37, 75–109 (1982).
Kiessling, R. & Wigzell, H. Immun. Rev. 44, 165–208 (1979).
Castro, J. E., Hunt, R., Lance, E. M. & Medawar, P. B. Cancer Res. 34, 2055–2060 (1974).
Medawar, P. B. & Hunt, R. Nature 271, 164–165 (1978).
Sikora, K., Stern, P. & Lennox, E. Nature 269, 813–815 (1977).
Medawar, P. Cancer Res. 34, 2053–2054 (1974).
Evans, R. & Alexander, P. in Immunobiology of the Macrophage (ed. Nelson, D. S. ) 535–576 (Academic, New York, 1976).
Cook, J. L., Hibbs, J. B. & Lewis, A. M. Proc. natn. Acad. Sci. U.S.A. 77, 6773–6777 (1980).
Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A. & van der Eb, A. J. Nature 305, 771–775 (1983).
Hyman, R. & Stallings, V. J. natn. Cancer Inst. 52, 429–436 (1974).
Dunn, T. B. & Potter, M. J. natn. Cancer Inst. 18, 587–602 (1957).
Schulman, M., Wilde, C. D. & Kohler, G. Nature 276, 269–270 (1978).
Malawista, S. E. & Weiss, M. C. Proc. natn. Acad. Sci. U.S.A. 71, 927–931 (1974).
Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
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Brickell, P., Latchman, D., Murphy, D. et al. Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse. Nature 306, 756–760 (1983). https://doi.org/10.1038/306756a0
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DOI: https://doi.org/10.1038/306756a0
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