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Radiofrequency destruction of the tuberoinfundibular region of hypothalamus permanently abrogates NK cell activity in mice

Nature volume 306, pages 181–184 (1983)Cite this article

Abstract

Natural killer (NK) cells have an important role in non-adaptative resistance to tumours and their metastatic spread in vivo1–5. Maturation of NK cells and the intensity of their activity are affected by many endogenous and external factors, as well as by regulatory cells1. The possibility that some effects of the central nervous system on tumour resistance are mediated via NK activity has also been suggested6. Destruction of the tuberoinfundibular region of the hypothalamus in rodents led to a significant increase in tumour growth7–9. We show here that destruction of its ventromedial, dorsomedial and arcuate nuclei persistently abrogates NK activity in mice. By contrast, cortical lesion and operative stress depress it partially, and for a brief period only. Abrogation is the result of a block of NK lineage maturation, causing a severe decrease in the number of large granular lymphocytes (LGL), a lymphocyte population associated with NK activity10,11. Macrophage, B- and T-lymphocyte functions, however, are not significantly affected. Agents inducing NK-cell maturation or activation such as poly inosinic-polycytidylic acid (poly(I:C), interferon (IFN) and interleukin-2 (IL-2) restore NK activity, and normalize the number of LGL.

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References

  1. Herberman, R. B.(ed.) NK Cells and Other Natural Effector Cells (Academic, New York, 1982).

  2. Riccardi, C., Puccetti, P., Santoni, A. & Herberman, R. B. J. natn. Cancer. Inst. 63, 1041–1047 (1979).

    CAS  Google Scholar 

  3. Karre, D., Klein, G. O., Kiessling, R. & Roder, J. C. Nature 284, 624–626 (1980).

    Article  ADS  CAS  Google Scholar 

  4. Hanna, N. & Burton, R. C. J Immun. 127, 1754–1758 (1981).

    CAS  PubMed  Google Scholar 

  5. Warner, J. F. & Dennert, G. Nature 300, 31–34 (1980).

    Article  ADS  Google Scholar 

  6. Herberman, R. B. in Biological Mediators of Behaviour and Disease: Neoplasia (ed. Levy, S.) (Elsevier, Amsterdam, in the press).

  7. Bindoni, M., Belluardo, N., Licciardello, S., Marchese, A. E. & Cicirata, F. Expl Neurol. 67, 433–437 (1980).

    Article  CAS  Google Scholar 

  8. Bindoni, M., Belluardo, N., Licciardello, S., Marchese, A. E. & Cicirata, F. Neuroendocrinology 30, 88–93 (1980).

    Article  CAS  Google Scholar 

  9. Bindoni, M., Belluardo, N., Marchese, A. E., Mudo′, G. & Laguidara, A. Neuroendocr. Lett. 3, 347–363 (1981).

    Google Scholar 

  10. Timonen, T., Saksela, E., Ranki, A. & Hayry, P. Cell Immun. 48, 133–140 (1979).

    Article  CAS  Google Scholar 

  11. Kumagai, K., Itoh, K., Suzuki, R., Hinuma, S. & Saitoh, F. J. Immun. 129, 388–395d (1982).

    CAS  PubMed  Google Scholar 

  12. Lehmann, A. Atlas Stereotaxique du Cerveau de la Souris (Centre National Recherche Scientifique, Paris, 1974).

    Google Scholar 

  13. Santoni, A., Riccardi, C., Sorci, V. & Herberman, R. B. J. Immun. 126, 2329–2332 (1980).

    Google Scholar 

  14. Giovarelli, M., Landolfo, S., Whitmore, A. C. & Forni, G. Eur. J. Cancer 18, 307–315 (1982).

    Article  CAS  Google Scholar 

  15. Landolfo, S., Giovarelli, M., Viano, I. & Forni, G. Immunogenetics 9, 245–253 (1979).

    Article  Google Scholar 

  16. Julius, M., Simpson, E. & Herzenberg, L. W. Eur. J. Immun. 3, 465–469 (1973).

    Article  Google Scholar 

  17. Santoni, A., Herberman, R. B., Piccoli, M. & Ortaldo, J. Fedn Proc. 42, 1380 (1983).

    Google Scholar 

  18. Trinchieri, G. & Santoli, D. J. exp. Med. 143, 569–682 (1978).

    Google Scholar 

  19. Riccardi, C., Vose, B. M. & Herberman, R. B. in NK Cells and Other Natural Effector cells (ed. Herberman, R. B.) 909–915 (Academic, New York, 1982).

    Book  Google Scholar 

  20. Djeu, J. Y., Heinbaugh, J. A., Holden, H. T. & Herberman, R. B. J. Immun. 122, 175–181 (1979).

    CAS  Google Scholar 

  21. Kuribayashi, K., Gillis, S., Kern, D. E. & Henney, C. S. J. Immun. 126, 2321–2326 (1981).

    CAS  PubMed  Google Scholar 

  22. Saxena, Q. B., Saxena, R. K. & Adler, W. H. Int. Archs. Allergy appl. Immun. 67, 169–174 (1982).

    Article  CAS  Google Scholar 

  23. Talwor, G. P. et al. Recent Prog. Horm. Res. 31, 141–174 (1975).

    Google Scholar 

  24. Fabris, N., Pierpaoli, W. & Sorkin, E. Clin. exp. Immun. 9, 227–240 (1971).

    CAS  PubMed  Google Scholar 

  25. Mathews, P. M., Froelich, C. J., Sibbit, W. L. & Bankhurst, A. D. J. Immun. 130, 1658–1662 (1983).

    CAS  PubMed  Google Scholar 

  26. Solomon, G. F. & Amkkraut, A. A. A. Rev. Microbiol. 35, 155–184 (1981).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, University of Turin, Via Santena 9, 10126, Turin, Italy

    Guido Forni & Mirella Giovarelli

  2. Department of Physiology, University of Catania, Viale A. Doria 6, 95125, Catania, Italy

    Mauro Bindoni, Natale Belluardo & Anna E. Marchese

  3. Chair of Virology, University of Perugia, Via del Giochetto, 06100, Perugia, Italy

    Angela Santoni

Authors
  1. Guido Forni
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  2. Mauro Bindoni
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  3. Angela Santoni
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  4. Natale Belluardo
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  5. Anna E. Marchese
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  6. Mirella Giovarelli
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Forni, G., Bindoni, M., Santoni, A. et al. Radiofrequency destruction of the tuberoinfundibular region of hypothalamus permanently abrogates NK cell activity in mice. Nature 306, 181–184 (1983). https://doi.org/10.1038/306181a0

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