Abstract
The human HLA-D region-related loci encode antigens which are structurally homologous and functionally analogous to the murine Ia molecules in mice1. In addition to a role in immune regulation, it has been shown that the human D region-associated molecules are expressed on immature haematopoietic precursors and may also be involved in the regulation of haematopoiesis2–7. Here we present evidence that distinct ‘Ia-like’ antigens are found on different haematopoietic cells. Approximately half of the Ia-like molecules expressed by B cells and activated T cells have an ‘epitope’ which is unique to lymphocytes and is not detectable on the Ia-like molecules of haematopoietic precursors or monocytes. This kind of lineage-restricted variation in Ia expression is a potential basis for selective compartmentalization and regulation of DR-associated function.
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Torok-Storb, B., Nepom, G., Nepom, B. et al. HLA-DR antigens on lymphoid cells differ from those on myeloid cells. Nature 305, 541–543 (1983). https://doi.org/10.1038/305541a0
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DOI: https://doi.org/10.1038/305541a0
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