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Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides

Nature volume 304, pages 699–703 (1983)Cite this article

Abstract

Five peptides containing amino acid sequences from the type 1 poliovirus structural protein VP1 have been synthesized. Each of the peptides was found capable of priming the immune system of rabbits for a long-lasting, virus-neutralizing IgG antibody response following a single inoculation of intact virus. One peptide directly induced the production of neutralizing antibody.

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Author information

Author notes

  1. Emilio A. Emini

    Present address: Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania, 19486, USA

Authors and Affiliations

  1. Department of Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York, 11794, USA

    Emilio A. Emini, Bradford A. Jameson & Eckard Wimmer

Authors
  1. Emilio A. Emini
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  2. Bradford A. Jameson
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  3. Eckard Wimmer
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Emini, E., Jameson, B. & Wimmer, E. Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides. Nature 304, 699–703 (1983). https://doi.org/10.1038/304699a0

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