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Selection and properties of a mouse L-cell transformant expressing human transferrin receptor

Nature volume 304, pages 643–645 (1983)Cite this article

Abstract

Transferrin receptors are expressed in large quantities on tissues with high requirements for iron such as maturing erythroid cells and placenta. In addition, they are found in abundance on proliferating cells from other normal tissues1–5 as well as on a variety of tumours4–8. Recent genetic analysis has shown that structural genes for the transferrin receptor, probably transferrin itself and for p97, a melanoma-associated antigen that exhibits primary sequence homology with transferrin and that can bind ferric iron, each map in man to chromosome 3 (refs 9–12). On this basis it has been suggested that there may be a region on chromosome 3 containing genes involved in Fe transport and that rearrangements in this region of chromosome 3 may in some circumstances be associated with malignant transformation12. Furthermore, it is unresolved whether all cell types express structurally identical transferrin receptors13,14. To study these problems, and as an initial step towards cloning the transferrin receptor gene, we describe here the derivation of mouse L-cell transformants expressing the human transferrin receptor.

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Authors and Affiliations

  1. The Salk Institute for Biological Studies, PO Box 85800, San Diego, California, 92138, USA

    Roland Newman, Derrick Domingo, Joseph Trotter & Ian Trowbridge

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  1. Roland Newman
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  2. Derrick Domingo
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  3. Joseph Trotter
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  4. Ian Trowbridge
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Newman, R., Domingo, D., Trotter, J. et al. Selection and properties of a mouse L-cell transformant expressing human transferrin receptor. Nature 304, 643–645 (1983). https://doi.org/10.1038/304643a0

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