Abstract
The hallmark of retroviral transforming genes (onc genes) are specific sequences which are unrelated to essential virion genes but are closely related to sequences in normal cells. Viral onc genes probably originated from rare transductions of these cellular sequences by retroviruses without onc genes. Consequently, it has been suggested that retroviral transforming genes are present in normal cells in a latent form. However, recent structural analyses indicate that viral onc genes and cellular genes, which share specific sequences, are not isogenic. They differ from each other in scattered point mutations and in unique coding regions. The cellular genes containing onc-related sequences are expressed in normal cells compatible with a normal function. There is as yet no functional or consistent circumstantial evidence that these cellular genes cause cancer in animals that are not infected by viruses with onc genes. Therefore, it is still uncertain whether the onc-related cellular genes have oncogenic potential beyond their role as progenitors of retroviral onc genes.
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References
Duesberg, P. H. Cold Spring Harb. Symp. quant. Biol. 44, 13–29 (1980).
Tooze, J. The Molecular Biology of Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1973).
Weiss, R. A., Teich, N. M., Varmus, H. & Coffin, J. M. The Molecular Biology of Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1982).
Gross, L. Oncogenic Viruses (Pergamon, New York, 1970).
Huebner, R. J. & Todaro, G. J. Proc. natn. Acad. Sci. U.S.A. 64, 1087–1094 (1969).
Bister, K. & Duesberg, P. H. in Advances in Viral Oncology Vol. 1 (ed. Klein, G.) 3–42 (Raven, New York, 1982).
Temin, H. M. J. natn. Cancer Inst. 46, 3–7 (1971).
Duesberg, P. H. & Vogt, P. K. Proc. natn. Acad. Sci. U.S.A. 67, 1673–1680 (1970).
Martin, G. S. & Duesberg, P. H. Virology 47, 494–497 (1972).
Duesberg, P. H. & Vogt, P. K. Virology 54, 207–219 (1973).
Lai, M. M. C., Duesberg, P. H., Horst, J. & Vogt, P. K. Proc. natn. Acad. Sci. U.S.A. 70, 2266–2270 (1973).
Maisel, J., Klement, V., Lai, M. M. C., Ostertag, W. & Duesberg, P. H. Proc. natn. Acad. Sci. U.S.A. 70, 3536–3540 (1973).
Lee, W-H. et al. Proc. natn. Acad. Sci. U.S.A. 77, 2018–2022 (1980).
Duesberg, P. H., Bister, K. & Vogt, P. K. Proc. natn. Acad. Sci. U.S.A. 74, 4320–4324 (1977).
Scolnick, E. M., Rands, E., Williams, D. & Parks, W. P. J. Virol. 12, 458–463 (1973).
Scolnick, E. M. & Parks, W. P. J. Virol. 13, 1211–1219 (1974).
Tsuchida, N., Gilden, R. V. & Hatanaka, M. Proc. natn. Acad. Sci. U.S.A. 71, 4503–4507 (1974).
Scolnick, E. M. Microbiol. Rev. 45, 1–8 (1981).
Stehelin, D., Varmus, H. E., Bishop, J. M. & Vogt, P. K. Nature 260, 170–173 (1976).
Frankel, A. & Fischinger, P. J. Proc. natn. Acad. Sci. U.S.A. 73, 3705–3709 (1976).
Chen, I. S. Y., Wilhelmsen, K. C. & Temin, H. M. J. Virol. 45, 104–113 (1983).
Frankel, A. E., Gilbert, H. J., Porzig, K. J., Scolnick, E. M. & Aaronson, S. A. J. Virol. 30, 821–827 (1979).
Vennstrom, B., Sheiness, D., Zabielski, J. & Bishop, J. M. J. Virol. 42, 773–779 (1982).
Colby, W. W., Chen, E. Y., Smith, D. H. & Levinson, H. D. Nature 30, 722–725 (1983).
Spector, D. H. et al. Cell 13, 371–379 (1978).
Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2194–2198 (1982).
Lee, W-H., Liu, C-P. & Duesberg, P. J. Virol. 44, 401–412 (1982).
Shilo, B-Z. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 78, 6789–6792 (1981).
Oskarrsson, M. K., McClements, W. L., Blair, D. S., Maizel, J. V. & Vande Woude, G. F. Science 207, 1222–1224 (1980).
Goff, S. P. & Baltimore, D. in Advances in Viral Oncology Vol. 1 (ed. Klein, G.) 127–139 (Raven, New York, 1982).
Lee, W-H., Nunn, M. & Duesberg, P. H. J. Virol. 39, 758–776 (1981).
Robins, T., Bister, K., Garon, C., Papas, T. & Duesberg, P. J. Virol. 41, 635–642 (1982).
Watson, D. K., Reddy, E. P., Duesberg, P. H. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 80, 2146–2150 (1983).
Lee, W-H., Phares, W. & Duesberg, P. H. Virology (in the press).
Van Beveren, C. et al. Nature 289, 258–262 (1981).
Klempnauer, K-H., Gonda, T. J. & Bishop, J. M. Cell 31, 453–463 (1982).
Shalloway, D., Zelenetz, A. D. & Cooper, G. M. Cell 24, 531–542 (1981).
Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).
Bishop, J. M. Cell 23, 5–6 (1981).
Mellon, P., Pawson, A., Bister, K., Martin, G. S. & Duesberg, P. H. Proc. natn. Acad. Sci. U.S.A. 75, 5874–5878 (1978).
Mathey-Prevot, B., Hanafusa, H. & Kawai, S. Cell 28, 897–906 (1982).
Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).
Takeya, T. & Hanafusa, H. Cell 32, 881–890 (1983).
Wang, S. Y., Hayward, W. S. & Hanafusa, H. J. Virol. 24, 64–73 (1977).
Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).
Smart, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 78, 6013–6017 (1981).
Mellon, P. & Duesberg, P. Nature 270, 631–634 (1977).
Josephs, S. F., Dalla Favera, R., Gelmann, E. P., Gallo, R. C. & Wong-Staal, F. Science 219, 503–505 (1983).
Devare, S. G., Reddy, E. P., Law, J. D., Robbins, K. C. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 80, 731–735 (1983).
Ellis, R. W., Lowy, D. R. & Scolnick, E. M. in Advances in Viral Oncology Vol. 1 (ed. Klein, G.) 107–126 (Raven, New York, 1982).
Dhar, R. et al. Science 217, 934–936 (1982).
Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33–37 (1983).
Ellis, R. W., DeFeo, D., Furth, M. E. & Scolnick, E. M. Molec. cell. Biol. 2, 1339–1345 (1982).
Reddy, E. P. et al. Proc. natn. Acad. Sci. U.S.A. 77, 5234–5238 (1980).
Van Beveren, C., Van Straaten, F., Curran, T., Müller, R. & Verma, I. M. Cell 32, 1241–1255 (1983).
Rushlow, K. E. et al. Science 216, 1421–1423 (1982).
Duesberg, P. H., Bister, K. & Moscovici, C. Proc. natn. Acad. Sci. U.S.A. 77, 5120–5124 (1980).
Boyle, W. J., Lipsich, J. S., Reddy, E. P. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 80, 2834–2898 (1983).
Chen, J. H. J. Virol. 36, 162–170 (1980).
Gonda, T. J. & Bishop, J. M. J. Virol. 46, 212–220 (1983).
Bister, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3677–3681 (1982).
Hanafusa, H., Halpern, C. C., Buchhagen, D. C. & Kawai, S. J. exp. Med. 145, 1735–1737 (1977).
Martin, G. S., Lee, W-H. & Duesberg, P. H. J. Virol. 36, 591–594 (1980).
Wang, L-H., Halpern, C. C., Nadel, M. & Hanafusa, H. Proc. natn. Acad. Sci. U.S.A. 75, 5812–5816 (1978).
Ramsay, G. M., Enrietto, P. J., Graf, T. & Hayman, M. J. Proc. natn. Acad. Sci. U.S.A. 79, 6885–6889 (1982).
Vigne, R., Breitman, M., Moscovici, C. & Vogt, P. K. Virology 93, 413–426 (1979).
Blair, D. G. et al. Science 212, 941–943 (1981).
Chang, E. H., Furth, M. E., Scolnick, E. M. & Lowy, D. R. Nature 297, 479–483 (1982).
Kriegler, M. & Botchan, M. Molec. cell. Biol. 3, 325–339 (1983).
DeFeo, D. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3328–3332 (1981).
Müller, R., Harmon, D. J., Tremblay, J. M., Cline, M. J. & Verma, I. M. Nature 299, 640–644 (1982).
Gorgette, M., Petropoulos, C. J., Shank, P. R. & Fausto, N. Science 219, 510–512 (1983).
Watson, R., Oskarsson, M. & Vande Woude, G. F. Proc. natn. Acad. Sci. U.S.A. 79, 4078–4082 (1982).
Takeya, T. & Hanafusa, H. J. Virol. 44, 12–18 (1982).
Tabin, C.J. et al. Nature 300, 143–149 (1982).
Reddy, E. P., Reynolds, R. K., Santos, E. & Barbacid, M. Nature 300, 149–152 (1982).
Der, J.C., Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).
Cooper, G. M. Science 217, 801–806 (1982).
Feinberg, A. P., Vogelstein, B., Droller, M. J., Baylin, S. B. & Nelkin, B. D. Science 220, 1175–1177 (1983).
Rubin, H. Science 219, 1170–1171 (1983).
Logan, J. & Cairns, J. Nature 300, 103–105 (1982).
Rechavi, G., Givol, D. & Canaani, E. Nature 300, 607–611 (1982).
Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).
Payne, G. S., Bishop, J. M. & Varmus, H. E. Nature 295, 209–214 (1982).
Saedler, H., Reif, H. I., Hu, S. & Davidson, N. Molec. gen. Genet. 132, 265–289 (1974).
Lautenberger, J. A., Schulz, R. A., Garon, C. F., Tsichlis, P. H. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 78, 1518–1522 (1981).
Quade, K. Virology 98, 461–465 (1979).
Cooper, G. A. & Neiman, P. E. Nature 292, 857–858 (1981).
Goubin, G., Goldman, D. S., Luce, J., Neiman, P. E. & Cooper, G. M. Nature 302, 114–119 (1983).
Tsichlis, P. N., Strauss, P. G. & Hu, L. F. Nature 302, 445–449 (1983).
Yoshimura, F. K. & Levine, K. L. L. Virol. 45, 576–584 (1983).
Kettmann, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2465–2469 (1982).
Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2490–2494 (1982).
Scolnick, E. M., Weeks, M. O., Shih, T. Y., Ruscetti, S. K. & Dexter, T. M. Molec. cell. Biol. 1, 66–74 (1981).
Eva, A. et al. Nature 295, 116–119 (1982).
Cairns, J. Nature 289, 353–357 (1981).
Klein, G. Nature 294, 313–318 (1981).
Marcu, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 80, 519–523 (1983).
Klein, G. Cell 32, 311–315 (1983).
Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6966–6970 (1982).
Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443–452 (1982).
Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).
Dalla-Favera, R., Martinotti, S. & Gallo, R. C. Science 219, 963–967 (1983).
Erikson, J., ar-Rushidi, A., Drwinga, H. L., Nowell, P. C. & Croce, C. M. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).
Crews, S., Barth, R., Hood, L., Prehn, J. & Calame, K. Science 218, 1319–1321 (1982).
Rowley, J. D. Nature 301, 290–291 (1983).
Yunis, J.J. et al. New Engl. J. of Med. 307, 1231–1236 (1982).
deKlein, A. et al. Nature 300, 765–767 (1982).
Fialkow, P.J. et al. Blood 58, 158–163 (1981).
Dalla-Favera, R. D., Wong-Staal, F. & Gallo, R. C. Nature 299, 61–63 (1982).
Collins, S. & Groudine, M. Nature 298, 679–681 (1982).
Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E. & Bishop, J. M. Proc. natn. Acad. Sci. U.S.A. 80, 1707–1711 (1983).
Alt, F. W., Kellems, R. E., Bertino, J. R. & Schimke, R. T. J. biol. Chem. 253, 1357–1370 (1978).
Murray, M. J. et al. Cell 25, 355–361 (1981).
Schwab, M. et al. Nature 303, 497–501 (1983).
Chattopadhyay, S. K. et al. Nature 296, 361–363 (1982).
Knudson, A. G. Cancer Vol. 1 (ed. Becker, F.) 73–88 (Plenum, New York, 1981).
Berenblum, I. Cancer Vol. 1 (ed. Becker, F.) 451–484 (Plenum, New York, 1981).
Bister, K. & Duesberg, P. H. Proc. natn. Acad. Sci. U.S.A. 76, 5023–5027 (1979).
Frykberg, L. et al. Cell 32, 227–238 (1983).
Balmain, A. & Pragnell, I. B. Nature 303, 72–74 (1983).
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Duesberg, P. Retroviral transforming genes in normal cells?. Nature 304, 219–226 (1983). https://doi.org/10.1038/304219a0
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DOI: https://doi.org/10.1038/304219a0
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