Abstract
There is substantial evidence that oncogenes (v-onc) of acute transforming retroviruses have been acquired by transduction of cellular genes (c-onc) with retroviruses1,2. Feline leukaemia virus (FeLV)-associated feline fibrosarcomas have proven to be extremely useful for the isolation of acute transforming retroviruses of a mammalian species. Three different v-onc genes have been identified in five acute transforming feline retroviruses. The Susan McDonough feline sarcoma virus (SM-FeSV)3 contains the oncogene fms (ref. 4). The Snyder–Theilen (ST)5 and Gardner–Arnstein (GA)6 FeSVs contain the oncogene fes (ref. 4), which is homologous to the oncogene fps of the avian sarcoma viruses FSV, RRCII, PRCIV and 16L (refs 7, 8). The v-onc sequences of the Parodi–Irgens (PI) FeSV have recently been found to be homologous with the v-sis sequences of the simian sarcoma virus9,10. We report here the isolation of another acute transforming feline retrovirus from a naturally occurring feline fibrosarcoma, designated the Hardy–Zuckerman 2 feline sarcoma virus (HZ2-FeSV) and demonstrate that the HZ2-FeSV and Abelson murine leukaemia virus (A-MuLV) have homologous oncogenes.
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Besmer, P., Hardy, W., Zuckerman, E. et al. The Hardy–Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV. Nature 303, 825–828 (1983). https://doi.org/10.1038/303825a0
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DOI: https://doi.org/10.1038/303825a0
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