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Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination

Nature volume 302, pages 256–258 (1983)Cite this article

Abstract

Recent experiments in the murine system1,2 have indicated that the passive acquisition by offspring of maternal anti-malarial IgG antibodies while conferring some degree of immunity against a primary infection, paradoxically prevents the generation of acquired immunity through vaccination. Therefore, in view of earlier findings3 concerning the competitive effects of specific IgM and IgG antibodies, we investigated whether specific monoclonal IgM antibodies could be used to potentiate the response to a blood-stage murine malaria vaccine. We now report that small amounts of purified monoclonal anti-parasite IgM can specifically potentiate both priming and memory cell generation in response to vaccination as evidenced by survival after infection, and that the magnitude of this effect is greater than that found with a more conventional nonspecific adjuvant (Bordetella pertussis). Additionally, in offspring of immune mothers, where vaccination is ineffective for up to 8 weeks due to the presence of maternal IgG1,2, we have found that IgM when administered with the vaccine can completely overcome this inhibition by its adjuvant effect.

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Author notes

  1. P. G. Harte

    Present address: Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Gower Street, London, WC1E 7HT, UK

Authors and Affiliations

  1. Department of Immunology, The Middlesex Hospital Medical School, London, W1P 9PG, UK

    P. G. Harte, A. Cooke & J. H. L. Playfair

Authors
  1. P. G. Harte
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  2. A. Cooke
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  3. J. H. L. Playfair
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Harte, P., Cooke, A. & Playfair, J. Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination. Nature 302, 256–258 (1983). https://doi.org/10.1038/302256a0

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