Abstract
Mice that have been specially bred to lack a protein known as Grf-1, which is normally found only in the brain, do not grow properly after they are born and remain small all their lives. We have now identified a function of Grf-1 as an important regulator of the synthesis and release of growth hormone. Moreover, grf1, the gene encoding this protein, is unlike other imprinted genes that affect growth because it operates after, rather than before, birth.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zippel, R. et al. Mol. Brain Res. 48, 140–144 (1997).
Feig, L. A. Curr. Opin. Cell Biol. 6, 204–211 (1994).
Lowy, D. & Willumsen, B. Annu. Rev. Biochem. 62, 851- 891 (1993).
Cen, H., Papageorge, A. G., Kippel, R., Lowy, D. R. & Zhang, K. EMBO J. 11, 4001–4015 (1992).
Fam, N. P. et al. Mol. Cell Biol. 17, 1396–1406 (1997).
Plass, C. et al. Nature Genet. 14, 106–109 ( 1996).
Bertherat, J., Bluet-Pajot, M. & Epelbaum, J. Eur. J. Endocrinol. 132, 12–24 (1995).
Mattingly, R. R. & Macara, I. G. Nature 382, 268–272 (1996).
Brambilla, R. et al. Nature 390, 281–286 (1997).
Jaenisch, R. Trends Genet. 13, 323–329 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Itier, JM., Tremp, G., Léonard, JF. et al. Imprinted gene in postnatal growth role. Nature 393, 125–126 (1998). https://doi.org/10.1038/30120
Issue Date:
DOI: https://doi.org/10.1038/30120
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
