Abstract
Human T-cell leukaemia virus (HTLV) has been isolated from several cases of cutaneous T-cell lymphoma in the United States1,2. Subsequently, adult T-cell leukaemia virus (ATLV) was also isolated from several cases of adult T-cell leukaemia in Japan3–5. Since the latter disease has been shown to be correlated ≥90% with the presence of high titred natural antibodies6–8 to two structural proteins of HTLV [p24 (ref. 9) and p19 (ref. 10)], it was important to compare HTLV and ATLV. We report here that by serology of p24 and p19 and by nucleic acid homology, ATLV appears to be as closely related to the original isolate of HTLV as different isolates of HTLV (from various regions of the world) are related to each other. ATLV is therefore either identical or closely related to HTLV.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Poiesz, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).
Poiesz, B. J., Ruscetti, F. W., Reitz, M. S., Kalyanaraman, V. S. & Gallo, R. C. Nature 294, 268–271 (1981).
Hinuma, Y. et al. Proc. natn. Acad. Sci. U.S.A. 78, 6476–6480 (1981).
Miyoshi, I. et al. Nature 294, 770–771 (1981).
Yoshida, M., Miyoshi, I. & Hinuma, Y. Proc. natn. Acad. Sci. U.S.A. 79, 2031–2035 (1982).
Robert-Guroff, M. et al. Science 215, 975–978 (1982).
Kalyanaraman, V. S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 1653–1657 (1982).
Gallo, R. C. et al. in Biochemical and Biological Markers on Neoplastic Transformation (Plenum, New York, in the press).
Kalyanaraman, V. S., Sarngadharan, M. G., Poiesz, B., Ruscetti, F. W. & Gallo, R. C. J. Virol. 38, 906–915 (1981).
Robert-Guroff, M., Ruscetti, F. W., Posner, L. E., Poiesz, B. J. & Gallo, R. C. J. exp. Med. 154, 1957–1964 (1981).
Catovsky, D. et al. Lancet i, 639–643 (1982).
Blattner, W. A. et al. Int. J. Cancer (in the press).
Morgan, D. A., Ruscetti, F. W. & Gallo, R. C. Science 193, 1007–1008 (1976).
Ruscetti, F. W., Morgan, D. A. & Gallo, R. C. J. Immun. 119, 131–138 (1977).
Poiesz, B. J., Ruscetti, F. W., Mier, J. W., Woods, A. M. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 77, 6815–6819 (1980).
Mier, J. W. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 77, 6134–6138 (1980).
Mier, J. W. & Gallo, R. C. J. Immun. 128, 1122–1127 (1982).
Reitz, M. S., Poiesz, B. J., Ruscetti, F. W. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 78, 1887–1891 (1981).
Gallo, R. C. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Kalyanaraman, V. S., Sarngadharan, M. G., Bunn, P. A., Minna, J. D. & Gallo, R. C. Nature 294, 271–273 (1981).
Posner, L. E. et al. J. exp. Med. 154, 333–346 (1981).
Uchiyama, T., Yodoi, J., Sagawa, K., Takatsuki, K. & Uchino, H. Blood 50, 481–492 (1977).
Rho, H. M., Poiesz, B., Ruscetti, F. W. & Gallo, R. C. Virology 112, 355–360 (1981).
Oroszlan, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 1291–1294 (1982).
Boone, L. R. & Skalka, A. Proc. natn. Acad. Sci. U.S.A. 77, 847–851 (1980).
Collins, S., Gallo, R. C. & Gallagher, R. E. Nature 270, 347–349 (1977).
Uchiyama, T., Broder, S., Bonnard, G. & Waldmann, T. Trans. Am. Ass. Phys. 93, 251–262 (1980).
Robert-Guroff, M. et al. J. exp. Med. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Popovic, M., Reitz, M., Sarngadharan, M. et al. The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group. Nature 300, 63–66 (1982). https://doi.org/10.1038/300063a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/300063a0
This article is cited by
-
Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy
BMC Immunology (2017)
-
Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation
Leukemia (2011)
-
A historical reflection on the discovery of human retroviruses
Retrovirology (2009)
-
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients
Leukemia (2009)
-
The discovery of the first human retrovirus: HTLV-1 and HTLV-2
Retrovirology (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.