Abstract
Murine retroviruses which cause sarcomas also induce abnormal proliferation of haematopoietic cells leading to death in newborn1–5 and, in some cases, adult4 mice. A murine sarcoma virus is a complex of a replication-defective sarcoma virus and a replication-competent murine leukaemia virus (MuLV). Cloned MuLV isolates also cause abnormal haematopoietic cell proliferations6–9. It is unknown whether such proliferative responses are direct effects of retroviruses on haematopoietic progenitor cells or indirect effects on other cells, which in turn provide the stimuli for the proliferation of haematopoietic cells. We demonstrate here that specific fibroblastic cell lines produce low levels of granulocyte–macrophage colony stimulating activity (GM–CSA) and that infection of certain fibroblast lines with murine retroviruses results in large increases in GM–CSA. Other cell lines which do not produce detectable CSA when uninfected do not produce it after retroviral infection.
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Koury, M., Pragnell, I. Retroviruses induce granulocyte–macrophage colony stimulating activity in fibroblasts. Nature 299, 638–640 (1982). https://doi.org/10.1038/299638a0
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DOI: https://doi.org/10.1038/299638a0
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