Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma

Nature volume 298, pages 474–476 (1982)Cite this article

Abstract

Burkitt's-type lymphomas–leukaemias (BL) are monoclonal proliferations of malignant B lymphocytes1. Irrespective of whether they carry the Epstein–Barr virus (EBV) genome, these tumour cells have been shown consistently to have one of the specific reciprocal chromosome translocations, t(8; 14), t(2; 8) or t(8; 22), involving the long arm of chromosome 8 (on 8q24) and chromosome 14,2 or 22 (on 14q32,2p12 and 22q11, respectively) 2–6. The latter chromosomes have been shown recently to carry genes for immunoglobulin (Ig) heavy chains7,8, and κ 9 and λ 10,11 light chains, respectively. Furthermore, the localization of κ light chains within 2pcen–2p13 encompasses the breakpoint observed in Burkitt's translocation (2p12). It was therefore considered of interest to determine whether the expression of immunoglobulin chains in BL cells is related to the type of chromosomal anomalies observed. We report here that there is a direct relationship between expression of immunoglobulin light chains and specific type of translocation: BL cells with t(8; 22) express λ chains, whereas those with t(2; 8) express κ chains.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Preud'homme, J. L., Brouet, J. C., Danon, F., Flandrin, G. & Schaison, G. J. natn. Cancer Inst. 66, 261–264 (1981).

    CAS  Google Scholar 

  2. Zech, L., Haglund, U., Nilsson, K. & Klein, G. Int. J. Cancer 17, 47–56 (1976).

    Article  CAS  Google Scholar 

  3. Van den Berghe, H. et al. Cancer Genet. Cytogenet. 1, 9–14 (1979).

    Article  Google Scholar 

  4. Miyoshi, I., Hiraki, S., Kimura, I., Miyamoto, K. & Sato, J. Experientia 35, 742 (1979).

    Article  CAS  Google Scholar 

  5. Berger, R. et al. Hum. Genet. 53, 111–112 (1979).

    Article  ADS  CAS  Google Scholar 

  6. Bernheim, A., Berger, R. & Lenoir, G. C.r. hebd. Séanc. Acad. Sci., Paris 291, 237–239 (1980).

    CAS  Google Scholar 

  7. Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 3416–3419 (1979).

    Article  ADS  CAS  Google Scholar 

  8. Hobart, M. J. et al. Ann. hum. Genet. 45, 331–335 (1981).

    Article  CAS  Google Scholar 

  9. Malcolm, S. et al. 6th Int. Workshop on Human Gene Mapping, Oslo, 29 June–3 July (National Foundation-March of Dimes, New York, 1981).

  10. McBride, O. W., Swan, D., Leder, P., Hieter, P. & Hollis, G. 6th Int. Workshop on Human Gene Mapping, Oslo, 29 June–3 July (National Foundation-March of Dimes, 1981).

  11. Erikson, J., Martinis, J. & Croce, C. M. Nature 294, 173–175 (1981).

    Article  ADS  CAS  Google Scholar 

  12. I.C.S.N. An Int. System for Human Cytogenetics Nomenclature. Birth Defects Original Article Ser., Vol. 14, 8 (1978).

  13. Preud'homme, J. L. & Labaume, S. in In vitro Methods in Cell-mediated and Tumor Immunity (eds Bloom, B.R. & David, J. J.) 155–169 (Academic, New York, 1976).

    Google Scholar 

  14. Miyoshi, I. et al. New Engl. J. Med. 304, 734 (1981).

    CAS  PubMed  Google Scholar 

  15. Tanzer, J., Frocrain, C., Alcalay, D. & Desmaret, M. C. Nouv. Revue fr. Hemat. 22, Suppl., 107 (1980).

    Google Scholar 

  16. Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

    Article  ADS  CAS  Google Scholar 

  17. Wiener, F., Babonits, M., Spira, J., Klein, G. & Potter, M. Somatic Cell Genet. 6, 731–738 (1980).

    Article  CAS  Google Scholar 

  18. Klein, G. Nature 294, 313–318 (1981).

    Article  ADS  CAS  Google Scholar 

  19. Philip, T. et al. Int. J. Cancer 28, 417–420 (1981).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, Cedex 2, France

    G. M. Lenoir

  2. Laboratory of Immunochemistry and Immunopathology, INSERM U 108, Hôpital St Louis, 75475, Paris, Cedex 10, France

    J. L. Preud'homme

  3. Laboratory of Immunology and Immunopathology, CHUR la Milétrie, 86021, Poitiers Cedex, France

    J. L. Preud'homme

  4. Laboratory of Cytogenetics, Institut de Recherches sur les Leucémies et Maladies du Sang, UER d'Hématologie, Hôpital St Louis, 2 place du Dr Fournier, 75475, Paris, Cedex 10, France

    A. Bernheim & R. Berger

Authors
  1. G. M. Lenoir
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. L. Preud'homme
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Bernheim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lenoir, G., Preud'homme, J., Bernheim, A. et al. Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma. Nature 298, 474–476 (1982). https://doi.org/10.1038/298474a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/298474a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing