Abstract
The in vitro growth of immature erythroid precursors, assayed as burst forming units (BFU–E), can be enhanced by co-culturing with normal T cells1–3. The growth enhancing effect of normal T cells, however, was shown to be the outcome of at least two functionally distinct subpopulations, one that enhances burst formation and one that limits it3,4. It appears that the T cell population limiting growth enhancement of the erythroid precursors expresses ‘Ia-like’ antigen (Ia+) because treatment of T cells with anti-Ia antibody and complement significantly increased the ability of the remaining T cells to stimulate antologous BFU–E growth3. As BFU–E also seem to express Ia, the inhibiting effect of certain T cells on BFU–E growth may involve the Ia molecule. We show here that the inhibitory effect of Ia+ T cells on BFU–E growth is genetically restricted to cell combinations which are phenotypically identical for at least one HLA–DR (Ia-like) antigen.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nathan, D. G. et al. J. exp. Med. 147, 324–339 (1978).
Mangan, K. F. & Desforges, J. F. Expl Hematol. 8, 717–727 (1980).
Torok-Storb, B., Martin, P. J. & Hansen, J. A. Blood 58, 171–174 (1981).
Torok-Storb, B., Martin, P. J. & Hansen, J. A. in Hemoglobin in Development and Differentiation (eds Stamatoyannopoulos, G. & Nienhius, A. W.) 137–143 (Liss, New York, 1981).
Hansen, J. A., Martin, P. J. & Nowinski, R. C. Immunogenetics 10, 247–260 (1980).
Robinson, J., Sieff, C., Delia, D., Edwards, P. A. W. & Greaves, M. Nature 289, 68–71 (1981).
Lipton, J. M. et al. J. exp. Med. 152, 350–360 (1980).
Winchester, R. J. & Kunkel, H. G. Adv. Immun. 28, 221–292 (1979).
Bernstein, I. D., Andrews, R. G., Cohen, S. F. & McMaster, B. E. J. Immun. 128, 876–881 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Torok-Storb, B., Hansen, J. Modulation of in vitro BFU–E growth by normal Ia-positive T cells is restricted by HLA–DR. Nature 298, 473–474 (1982). https://doi.org/10.1038/298473a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/298473a0
This article is cited by
-
Lymphocyte subsets in hemodialysis patients treated with recombinant human erythropoietin
Journal of Clinical Immunology (1993)
-
HLA-class II antigens on human hematopoietic progenitors
Blut (1987)
-
The function of lymphocytes in normal and suppressed hematopoiesis
Blut (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.