Abstract
Embryo DNA of AKR mice contains several copies of intact mink cell focus-forming (MCF)-like env gene sequences with a proviral structure. In spontaneous thymic tumours, these MCF-like env sequences have regularly recombined with a specific region of the 3′ end of ecotropic env. This specific recombination is probably a critical event in the pathogenesis of spontaneous AKR tumours.
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Chattopadhyay, S., Cloyd, M., Linemeyer, D. et al. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature 295, 25–31 (1982). https://doi.org/10.1038/295025a0
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DOI: https://doi.org/10.1038/295025a0
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