Abstract
The immunoglobulin λ light chain locus of man contains six λ-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. The sequences of three of these genes correspond to three known non-allelic λ chain isotypes: Mcg, Ke−Oz− and Ke−Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, λ-like sequences have also been cloned, suggesting that the λ genes form an unexpectedly large family within the human genome.
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References
Brack, C., Hirama, M., Lenhard-Schuller, R. & Tonegawa, S. Cell 15, 1–14 (1978).
Bernard, O., Hozumi, N. & Tonegawa, S. Cell 15, 1133–1144 (1978).
Seidman, J. G. & Leder, P. Nature 276, 790–795 (1978).
Lenhard-Schuller, R., Hohn, B., Brack, C., Hirama, M. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 75, 4709–4713 (1978).
Seidman, J. G., Max, E. E. & Leder, P. Nature 280, 370–375 (1979).
Seidman, J. G., Leder, A., Nau, M., Norman, B. & Leder, P. Science 202, 11–17 (1978).
Valbuena, O., Marcu, K. B., Weigert, M. & Perry, R. P. Nature 276, 780–784 (1978).
Max, E. E., Seidman, J. G. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 76, 3450–3454.
Sakano, H., Huppi, K., Heinrich, G. & Tonegawa, S. Nature 280, 288–294 (1979).
Weigert, M. et al. Nature 283, 497–499 (1980).
Hieter, P. A., Max, E. E., Seidman, J. G., Maizel, J. V. & Leder, P. Cell 22, 197–207 (1980).
Miller, J., Bothwell, A. & Storb, U. Proc. natn. Acad. Sci. U.S.A. 78, 3829–3833 (1981).
Blomberg, B., Traunecker, A., Eisen, H. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 78, 3765–3769 (1981).
Hieter, P. A., Korsmeyer, S. J., Waldmann, T. & Leder, P. Nature 290, 368–372 (1981).
Korsmeyer, S. J. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Ein, P. Proc. natn. Acad. Sci. U.S.A. 60, 982–985 (1968).
Gibson, D., Levannon, M. & Smithies, O. Biochemistry 10, 3114–3122 (1971).
Fett, J. & Deutsch, H. F. Immunochemistry 12, 643–652 (1975).
Solomon, A. Immunogenetics 5, 525–533 (1977).
Fett, J. W. & Deutsch, H. F. Immunochemistry 13, 149–155 (1976).
Lieu, T. S., Deutsch, H. F. & Tischendorf, T. W. Immunochemistry 24, 429–433 (1977).
Lopez de Castro, J. A., Chiu, Y. Y. H. & Poljak, R. J. Biochemistry 17, 1718–1723 (1978).
Maniatis, T. et al. Cell 15, 687–702 (1978).
Wyman, A. R. & White, R. Proc. natn. Acad. Sci. U.S.A. 77, 6754–6758 (1980).
Polsky, F., Edgell, M. H., Seidman, J. G. & Leder, P. Analyt. Biochem. 87, 397–410 (1978).
Bothwell, A. L. M. et al. Nature 290, 65–67 (1981).
Seif, I., Khoury, G. & Dhar, R. Nucleic Acids Res. 6, 3387–3389 (1979).
Konkel, D., Maizel, J. V. Jr & Leder, P. Cell 18, 865–873 (1979).
Southern, E. J. molec. Biol. 98, 503–517 (1975).
Rigby, P. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
Hood, L. E., Weissman, I. L. & Wood, W. B. in Immunology, 234 (Benjamin/Cummings, Menlo Park, California, 1978).
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Hieter, P., Hollis, G., Korsmeyer, S. et al. Clustered arrangement of immunoglobulin λ constant region genes in man. Nature 294, 536–540 (1981). https://doi.org/10.1038/294536a0
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DOI: https://doi.org/10.1038/294536a0
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