Abstract
Hormones can influence carcinogenesis in experimental animals1 and it has been proposed that sex hormones may act like tumour-promoting agents in their ability to enhance the incidence of cancer2. On the other hand, it has been observed that the glucocorticoid hormone, dexamethasone, suppresses the enhancement of chemical carcinogenesis in vivo2 and of transformation in vitro3 brought about by exposure to the tumour-promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We report here that the glucocorticoid hormones, cortisone and dexamethasone, do not suppress radiation transformation of C3H 10T½ cells in vitro. Indeed, cortisone induces transformation of cells by itself, and increases the yield of radiation-induced transformants in a synergistic fashion.
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Kennedy, A., Weichselbaum, R. Effects of dexamethasone and cortisone with X-ray irradiation on transformation of C3H 10T1/2 cells. Nature 294, 97–98 (1981). https://doi.org/10.1038/294097a0
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DOI: https://doi.org/10.1038/294097a0
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