Abstract
Ca2+ ions, involved in the control of many important physiological functions, require the presence of specific intracellular Ca2+-binding proteins to exert their regulatory roles. Many of the latter have been extracted and purified. Thus, troponin-C regulates muscle contraction1 and calmodulin is involved in a variety of fundamental cellular activities2,3. Parvalbumin seems to be restricted to muscle and brain4–6 but its physiological role is not yet clear. In muscle it probably participates in a regulatory system operating mainly in fast contracting muscles7,8, but in brain, even its anatomical distribution is unknown. We now describe the localization by immunohistological means of parvalbumin in neurones scattered throughout the central nervous system of the rat. Although the distributions of parvalbumin- and GABAergic neurones are similar, the physiological function of parvalbumin-immunoreactive neurones is not yet recognizable.
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References
Mannherz, H. G. & Goody, R. S. A. Rev. Biochem. 45, 427–465 (1976).
Means, A. R. & Dedman, J. R. Nature 285, 73–77 (1980).
Klee, C. B., Crouch, T. H. & Richman, P. G. A. Rev. Biochem. 49, 489–515 (1980).
Blum, H. E., Lehky, P., Kohler, L., Stein, E. A. & Fischer, E. H. J. biol. Chem. 252, 2834–2838 (1977).
Gosselin-Rey, C., Piront, A. & Gerday, C. Biochim. Biophys. Acta 532, 294–304 (1978).
Heizmann, C. W. & Strehler, E. E. J. biol. Chem. 254, 4296–4303 (1979).
Gillis, J. M. & Gerday, C. in Calcium Binding Proteins and Calcium Function (eds Wasserman, R. H. et al.) 193–196 (Elsevier, Amsterdam, 1977).
Pechère, J.-F., Derancourt, J. & Haiech, J. FEBS Lett. 75, 111–114 (1977).
Sternberger, L. A. in Immunocytochemistry, 104–169, (Wiley, New York, 1979).
Lin, C.-T., Dedman, J. R., Brinkley, B. B. & Means, A. R. J. Cell Biol. 85, 473–480 (1980).
Wood, J. G. et al. J. Cell Biol. 84, 66–76 (1980).
Brawshaw, R. A. & Schneider, P. M. Proteins of the Nervous System (Raven, New York, 1980).
Hagiwara, S. in Membranes Vol. 3 (ed. Eisenmann, G.) (Marcel Dekker, New York, 1975).
Llinás, R. & Sugimori, M. J. Physiol., Land. 305, 197–213 (1980).
Spitzer, A. A. Rev. Neurosci, 2, 363–397 (1979).
Ochs, S. & Worth, R. M. in Physiology and Pathobiology of Axons (ed. Waxman, S. G.) (Raven, New York, 1978).
Funnum, F. & Storm-Mathisen, J. in Handbook of Psychopharmakology, Vol. 9 (eds. Iversen, L. L., Iversen, S. D. & Sneider, S. H.) 357–401 (Plenum, New York, 1978).
Matsuda, T., Wu, Y. & Roberts, E. J. Neurochem. 21, 167–172 (1973).
Strehler, E. E., Eppenberger, H. M. & Heizmann, C. W. FEBS Lett. 78, 127–133 (1977).
Showe, M. D., Isobe, E. & Onorato, L. J. molec. Biol. 107, 55–69 (1976).
Jentoft, N. & Dearborn, D. G. J. biol. Chem. 294, 4359–4365 (1979).
Rose, M. J. Physiol. Neurol. 19, 119–207 (1912).
Pellegrino, L. J., Pellegrino, A. S. & Cushman, A. J. in A Stereotactic Atlas of the Rat Brain, 2nd edn (Plenum, New York, 1979).
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Celio, M., Heizmann, C. Calcium-binding protein parvalbumin as a neuronal marker. Nature 293, 300–302 (1981). https://doi.org/10.1038/293300a0
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DOI: https://doi.org/10.1038/293300a0
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