Abstract
Monoclonal antibodies1 are powerful tools for identifying antigenic molecules because they recognize a single antigenic site. In contrast, conventional immune sera contain mixtures of antibody molecules with a large variety of specificities. Some of these specificities may be cross-reactive with antigenic sites present on unrelated molecules, thus tending to decrease the overall recognition specificity. Such a cross-reactivity should be observed with some monoclonal antibodies, in which it might be expected to be both strong and specific (that is, directed against a restricted number of targets2). We report here such a cross-reactivity in a monoclonal antibody that recognizes equally well both Thy-1 (ref. 3) and a component of intermediate filaments, probably vimentin4,5.
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Dulbecco, R., Unger, M., Bologna, M. et al. Cross-reactivity between Thy-1 and a component of intermediate filaments demonstrated using a monoclonal antibody. Nature 292, 772–774 (1981). https://doi.org/10.1038/292772a0
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DOI: https://doi.org/10.1038/292772a0
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