Abstract
We report here that we have found an accumulation of condensed mitotic figures in cultures of various human haematopoietic cell lines treated with diazepam (40–80 µg ml−1). The mode of mitosis arresting activity of diazepam was analysed with cultured human fibroblasts. Unlike conventional anti-mitotic drugs, diazepam did not affect the microtubular integrity at the concentrations used. Instead, it seems to block mitosis by inhibiting the deviation of centrioles in the prometaphase.
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Andersson, L., Lehto, VP., Stenman, S. et al. Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation. Nature 291, 247–248 (1981). https://doi.org/10.1038/291247a0
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DOI: https://doi.org/10.1038/291247a0
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