Abstract
During the course of immunization of hybrid mice (genotype H–2b/k) with a parental Abelson virus-induced lymphoma (genotype H–2b/b), antibodies were produced to the H–2Kb or H–2Db antigens of the immunizing cells. Such ‘anti-self H–2’ antibodies demonstrate the existence of autoreactive B-cell clones in hybrid mice, and pose intriguing questions for the nature of self-tolerance.
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Risser, R., Grunwald, D. Production of anti-self H–2 antibodies by hybrid mice immune to a viral tumour. Nature 289, 563–568 (1981). https://doi.org/10.1038/289563a0
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DOI: https://doi.org/10.1038/289563a0
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