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Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes

Nature volume 288, pages 333–338 (1980)Cite this article

Abstract

A membrane receptor protein for asialoglycoproteins induces voltage-dependent increases in ion conductance across a lipid bilayer, probably reflecting penetration of the protein into the bilayer towards an electrically positive pole. In the presence of specific ligand for the receptor, this penetration leads to a ‘translocation’ of the receptor from one side of the bilayer to the other. These observations suggest a mechanism by which biological membranes might regulate the disposition of their proteins, and a way in which membrane receptors involved in endocytosis might be spared lysosomal destruction in order to be recycled to the plasma membrane.

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Authors and Affiliations

  1. Section on Membrane Structure and Function, LTB, DCBD, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205

    Robert Blumenthal, Richard D. Klausner & John N. Weinstein

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  1. Robert Blumenthal
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  2. Richard D. Klausner
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  3. John N. Weinstein
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Blumenthal, R., Klausner, R. & Weinstein, J. Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes. Nature 288, 333–338 (1980). https://doi.org/10.1038/288333a0

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