Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Sequence of retrovirus provirus resembles that of bacterial transposable elements

Nature volume 285, pages 550–554 (1980)Cite this article

An Erratum to this article was published on 31 July 1980

Abstract

The nucleotide sequences of the terminal regions of an infectious integrated retrovirus cloned in the modified λ phage cloning vector Charon 4A have been elucidated. There is a 569-base pair direct repeat at both ends of the viral DNA. The cell–virus junctions at each end consist of a 5-base pair direct repeat of cell DNA next to a 3-base pair inverted repeat of viral DNA. This structure resembles that of a transposable element and is consistent with the protovirus hypothesis that retroviruses evolved from the cell genome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Temin, H. M. Science 192, 1075–1080 (1976).

    Article  ADS  CAS  Google Scholar 

  2. Temin, H. M. J. natn. Cancer Inst. 46, III–VII (1971).

    CAS  Google Scholar 

  3. O.Rear, J. J., Mizutani, S., Hoffman, G., Fiandt, M. & Temin, H. M. Cell 20, 423–430 (1980).

    Article  CAS  Google Scholar 

  4. Hunter, E., Bhown, A. S. & Bennet, J. C. Proc. natn. Acad. Sci. U.S.A. 75, 2708–2712 (1978).

    Article  ADS  CAS  Google Scholar 

  5. Barbacid, M., Hunter, E. & Aaronson, S. A. J. Virol. 30, 508–514 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Bauer, G. & Temin, H. M. J. Virol. 34, 168–177 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Bukhari, A.-I. A. Rev. Genet. 10, 389–412 (1976).

    Article  CAS  Google Scholar 

  8. Cohen, S. Nature 263, 731–738 (1976).

    Article  ADS  CAS  Google Scholar 

  9. Starlinger, P. & Saedler, H. Curr. Topics Microbiol. Immun. 75, 111–152 (1976).

    CAS  Google Scholar 

  10. Nevers, P. & Saedler, H. Nature 206, 109–115 (1977).

    Article  ADS  Google Scholar 

  11. Kleckner, N. Cell 11, 11–23 (1977).

    Article  CAS  Google Scholar 

  12. Bukhari, A. I., Shapiro, J. A. & Adhya, S., (eds) DNA Insertion Elements, Plasmids and Episomes (Cold Spring Harbor Laboratory, New York, 1977).

  13. Smith, H. O. & Birnstiel, M. L. Nucleic Acids Res. 3, 2387–2398 (1976).

    Article  CAS  Google Scholar 

  14. Keshet, E., O'Rear, J. J. & Temin, H. M. Cell 16, 51–61 (1979).

    Article  CAS  Google Scholar 

  15. Shank, P. R. et al. Cell 15, 1383–1395 (1978).

    Article  CAS  Google Scholar 

  16. Sabran, J. L. et al. J. Virol. 29, 170–178 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Konkel, D. A., Tilghman, S. M. & Leder, P. Cell 15, 1124–1132 (1978).

    Article  Google Scholar 

  18. Goldberg, M. thesis, Stanford Univ. (1979).

  19. Ziff, E. B. & Evans, R. M. Cell 15, 1463–1475 (1978).

    Article  CAS  Google Scholar 

  20. Nishioka, Y. & Leder, P. Cell 18, 875–882 (1979).

    Article  CAS  Google Scholar 

  21. Proudfoot, N. J. J. molec. Biol. 197, 491–525 (1976).

    Article  Google Scholar 

  22. Hamlyn, P. H., Brownlee, G. G., Cheng, C. C., Gait, M. J. & Milstein, C. Cell 15, 1067–1075 (1978).

    Article  CAS  Google Scholar 

  23. Seeburg, P. H., Shine, J., Martial, J. A., Baxter, J. D. & Goodman, H. Nature 270, 486–494 (1977).

    Article  ADS  CAS  Google Scholar 

  24. Tucker, P. W., Marcu, K. B., Slightom, J. L. & Blattner, F. R. Science 206, 1299–1303 (1979).

    Article  ADS  CAS  Google Scholar 

  25. Coffin, J. M. J. gen. Virol. 42, 1–26 (1979).

    Article  CAS  Google Scholar 

  26. Haseltine, W. A., Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 989–993 (1977).

    Article  ADS  CAS  Google Scholar 

  27. Schwartz, D. W., Zamecnik, P. C. & Weith, H. L. Proc. natn. Acad. Sci. U.S.A. 74, 994–998 (1977).

    Article  ADS  CAS  Google Scholar 

  28. Stoll, E., Billeter, M. A., Palmenberg, A. & Weissmann, C. Cell 12, 57–72 (1977).

    Article  CAS  Google Scholar 

  29. Shine, J., Czeinilofsky, A. P., Friederick, R., Bishop, J. M. & Goodman, H. M. Proc. natn. Acad. Sci. U.S.A. 74, 1473–1477 (1977).

    Article  ADS  CAS  Google Scholar 

  30. Coffin, J. M. & Haseltine, W. A. Proc. natn. Acad. Sci. U.S.A. 74, 1908–1912 (1977).

    Article  ADS  CAS  Google Scholar 

  31. Coffin, J. M., Hageman, T. C., Maxam, A. M. & Haseltine, W. A. Cell 13, 761–773 (1978).

    Article  CAS  Google Scholar 

  32. Harada, F., Peters, G. & Dahlberg, J. G. J. biol. Chem. 254, 10979–10985 (1979).

    CAS  PubMed  Google Scholar 

  33. Haseltine, W. A., Kleid, D. G., Panet, A., Rothenberg, E. & Baltimore, D. J. molec. Biol. 106, 109–131 (1976).

    Article  CAS  Google Scholar 

  34. Rosenberg, M., Court, D., Shimatake, H., Brady, C. & Wulff, D. L. Nature 272, 414–423 (1978).

    Article  ADS  CAS  Google Scholar 

  35. Ghosal, D., Sommer, H. & Saedler, H. Nucleic Acids. Res. 6, 1111–1122 (1979).

    Article  CAS  Google Scholar 

  36. Ohtsubo, H., Ohmori, H. & Ohtsubo, E. Cold Spring Harb. Symp. quant. Biol. 43, 1269–1277 (1978).

    Article  Google Scholar 

  37. Allet, B. Cell 16, 123–129 (1979).

    Article  CAS  Google Scholar 

  38. Ravetich, J. V. et al. Proc. natn. Acad. Sci. U.S.A. 76, 2195–2198 (1979).

    Article  ADS  Google Scholar 

  39. Reed, R. R., Young, R. A., Steitz, J. A., Grindley, N. D. F. & Guyer, M. S. Proc. natn. Acad. Sci. U.S.A. 76, 4882–4885 (1979).

    Article  ADS  CAS  Google Scholar 

  40. Grindley, N. D. F. Cell 13, 419–426 (1978).

    Article  CAS  Google Scholar 

  41. Calos, M., Johnsnud, L. & Miller, J. H. Cell 13, 411–418 (1978).

    Article  CAS  Google Scholar 

  42. Ohtsubo, A. & Ohtsubo, E. in DNA Insertion Elements, Plasmids and Episomes (eds Bukhari, A. I., Shapiro, J. A. & Adhya, S.) 591–593 (Cold Spring Harbor Laboratory. New York, 1977).

    Google Scholar 

  43. Mizutani, S., Boettiger, D. & Temin, H. M. Nature 228, 424–427 (1970).

    Article  ADS  CAS  Google Scholar 

  44. Mizutani, S., Temin, H. M., Kodama, M. & Wells, R. D. Nature new Biol. 230, 232–235 (1971).

    Article  CAS  Google Scholar 

  45. Golomb, M. & Grandgenett, D. P. J. biol. Chem. 254, 1606–1613 (1979).

    CAS  PubMed  Google Scholar 

  46. Keshet, E. & Temin, H. M. Proc. natn. Acad. Sci. U.S.A. 75, 3372–3376 (1978).

    Article  ADS  CAS  Google Scholar 

  47. Tu, C.-P. D. & Cohen, S. N. Cell 19, 151–160 (1980).

    Article  CAS  Google Scholar 

  48. Saedler, H., Reif, J. H. & Davidson, N. Molec. gen. Genet. 132, 265–289 (1974).

    Article  CAS  Google Scholar 

  49. Benten, W. D. & Davis, R. W. Science 196, 180–182 (1977).

    Article  ADS  Google Scholar 

  50. Clewell, D. B. & Helinski, D. R. Proc. natn. Acad. Sci. U.S.A. 62, 1159–1166 (1969).

    Article  ADS  CAS  Google Scholar 

  51. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–565 (1977).

    Article  ADS  CAS  Google Scholar 

  52. Sanger, F. & Coulson, A. R. FEBS Lett. 87, 197–110 (1978).

  53. Korn, L. J., Queen, C. L. & Wegman, M. N. Proc. natn. Acad. Sci. U.S.A. 74. 4401–4405 (1977).

    Article  ADS  CAS  Google Scholar 

  54. Peters, G. G. & Glover, C. J. Virol. 33, 708–716 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, 53706

    Kunitada Shimotohno, Satoshi Mizutani & Howard M. Temin

Authors
  1. Kunitada Shimotohno
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Satoshi Mizutani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Howard M. Temin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shimotohno, K., Mizutani, S. & Temin, H. Sequence of retrovirus provirus resembles that of bacterial transposable elements. Nature 285, 550–554 (1980). https://doi.org/10.1038/285550a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/285550a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing