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Renin-like effects of NGF evaluated using renin-angiotensin antagonists

Nature volume 285, pages 248–250 (1980)Cite this article

Abstract

Intracranial injection of angiotensin II (AII) or activation of the cerebral isorenin–angiotensin system with intracranial renin causes an immediate thirst1 and a delayed sodium appetite2 in the rat. Nerve growth factor (NGF), a polypeptide trophic factor for peripheral sympathetic and sensory neurones3, has also been reported to be a potent stimulus to thirst4 and sodium appetite5 when injected into the brain of the rat. Lewis et al.5 drew attention to the marked similarity between the effects of 2.5S NGF and renin on thirst and sodium appetite and suggested that the NGF responses were mediated by the cerebral isorenin–angiotensin system. We report here that NGF-induced thirst and sodium appetite, as well as increased blood pressure and increased ornithine decarboxylase activity in the brain and liver, depend on the formation of AII (see also ref. 6).

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Authors and Affiliations

  1. Physiological Laboratory, University of Cambridge, Cambridge, CB2 3EG, UK

    D. B. Avrith, M. E. Lewis & J. T. Fitzsimons

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  1. D. B. Avrith
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  2. M. E. Lewis
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  3. J. T. Fitzsimons
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Avrith, D., Lewis, M. & Fitzsimons, J. Renin-like effects of NGF evaluated using renin-angiotensin antagonists. Nature 285, 248–250 (1980). https://doi.org/10.1038/285248a0

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