Abstract
Prostacyclin (prostaglandin I2, PGI2), produced by the blood vessel wall is the most potent known inhibitor of platelet aggregatión induced by such stimuli as ADP and thrombin1. It binds to a specific platelet receptor2 and activates adenylate cyclase, raising the cyclic AMP level in platelets3,4. This property can be important because platelets participate in several significant interactions. For example, the interaction with fibrinogen or fibrin contributes to the formation of the haemostatic plug5. Intact plasma fibrinogen is required for the aggregation of platelets induced by ADP6, and endogenous platelet fibrinogen influences thrombin-induced aggregation7. We have therefore studied the effect of prostacyclin on the interaction of fibrinogen with human platelets. We now report that prostacyclin inhibits the mobilisation of specific binding sites (‘receptors’) for fibrinogen on human platelets and that this effect parallels the inhibition of ADP- or thrombin-induced aggregation. The inhibitory effect of prostacyclin may limit the extent of platelet–fibrinogen interaction in vivo and in extracorporeal circulation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Moncada, S. & Vane, J. R. Br. med. Bull. 34, 129–135 (1978).
Siegl, A. M., Smith, J. B., Silver, M. J., Nicolau, K. C. & Ahern, D. J. clin. Invest. 63, 215–220 (1979).
Gorman, R. R., Bunting, S. & Miller, O. V. Prostaglandins 13, 377–388 (1977).
Best, L. C., Martin, T. J., Russell, R. G. G. & Preston, F. E. Nature 267, 850 (1977).
Sixma, J. J. & Wester, J. Semin. Hematol. 14, 265–299 (1977).
Niewiarowski, S., Budzynski, A. Z. & Lipinski, B. Blood 49, 635–644 (1977).
Tollefson, D. M. & Majerus, P. W. J. clin. Invest. 55, 1259–1268 (1975).
Timmons, S. & Hawiger, J. Thromb. Res. 12, 297–306 (1978).
Born, G. V. R. Nature 194, 927 (1962).
Hawiger, J., Hammond, D. K., Timmons, S. & Budzynski, A. Z. Blood 51, 799–812 (1978).
Miletich, J. P., Jackson, C. M. & Majerus, P. W. J. biol. Chem. 253, 6908–6916 (1978).
Steck, T. L. & Wallach, D. F. H. Biochim. biophys. Acta 97, 510–522 (1965).
Doolittle, R. F. in Plasma Proteins 2 (ed. Putnam, F. W.) 109–161 (Academic, New York, 1975).
Feagler, J. R., Tillack, T. W., Chaplin, D. D. & Majerus, P. W. J. Cell Biol. 60, 541–553 (1974).
Marguerie, G., Plow, E. F. & Edgington, T. S. J. biol. Chem. 254, 5357–5363 (1979).
Majerus, P. W. & Miletich, J. P. Am. Rev. Med. 29, 41–49 (1978).
Mills, D. C. B. & McFarlane, D. E. Thromb. Res. 5, 401–412 (1974).
Brodie, G. N., Baensinger, N. L., Chase, L. R. & Majerus, P. W. J. clin. Invest. 51, 81–88 (1972).
Marguerie, G., Plow, E. P. & Edgington, T. S. Thrombos. Haemostas., Stuttgart abstr. 42, 360 (1979).
White, J. G. in The Circulating Platelet (ed. Johnson, S. A.) 45–121 (Academic, New York, 1971).
Mustard, J. F., Packham, M. A., Kinlough-Rathbone, R. L., Perry, D. W. & Regoeczi, E. Blood 52, 453–466 (1978).
Woods, H. F., Ash, G., Weston, M. J., Bunting, S., Moncada, S. & Vane, J. R. Lancet ii, 1075–1077 (1978).
Rodvien, R. & Salzman, E. W. Thrombos. Haemostas., Stuttgart 39, 254–262 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hawiger, J., Parkinson, S. & Timmons, S. Prostacyclin inhibits mobilisation of fibrinogen-binding sites on human ADP- and thrombin-treated platelets. Nature 283, 195–197 (1980). https://doi.org/10.1038/283195a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/283195a0
This article is cited by
-
Inhibition of human platelet aggregation and membrane lipid peroxidation by food spice, saffron
Molecular and Cellular Biochemistry (2005)
-
Further insights into the anti‐aggregating activity of NMDA in human platelets
British Journal of Pharmacology (1998)
-
Direct demonstration of radiolabeled von willebrand factor binding to platelet glycoprotein Ib and IIb-IIIa in the presence of shear stress
Annals of Biomedical Engineering (1995)
-
The integrin αIIbβ3 as an antithrombotic target
Perspectives in Drug Discovery and Design (1994)
-
Functional and biochemical evidence of a specific adenosine A2/Ra receptor on human platelets *
La Ricerca in Clinica e in Laboratorio (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
