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Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

Nature volume 281, pages 452–455 (1979)Cite this article

Abstract

The RNAs of seven replication-defective leukaemia virus (DLV) strains contain three types of unique sequences, which correlate with the capacity of a given virus strain to transform erythroblasts, macrophage-like cells and myeloblasts, respectively. These sequences, termed erb, mac and myb, have their counterparts in the normal DNA of avian and mammalian species. Our results indicate that DLVs represent recombinants between a common ‘vector’ related to a chicken endogenous virus and one of three types of cellular gene possibly involved in haematopoietic differentiation.

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Author notes

  1. H. Beug and T. Graf: Institut für Virusforschung, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D6900 Heidelberg, FRG

Authors and Affiliations

  1. INSERM, Oncologie Moléculaire, Institut Pasteur de Lille, 15 rue C, Guérin, F 59000, Lille, France

    M. Roussel, S. Saule, C. Lagrou, C. Rommens, H. Beug, T. Graf & D. Stehelin

Authors
  1. M. Roussel
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  2. S. Saule
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  3. C. Lagrou
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  4. C. Rommens
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  5. H. Beug
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  6. T. Graf
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  7. D. Stehelin
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Roussel, M., Saule, S., Lagrou, C. et al. Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. Nature 281, 452–455 (1979). https://doi.org/10.1038/281452a0

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