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Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA

Nature volume 281, pages 40–46 (1979)Cite this article

Abstract

Mouse thymidine kinase-negative L cells were transformed with a cloned rabbit chromosomal β-globin gene linked to the cloned thymidine kinase gene of herpes simplex virus type 1. Most thymidine kinase-positive cell lines contained one or more copies of rabbit β-globin DNA and produced up to 2,000 copies of rabbit β-globin RNA per cell indistinguishable from its authentic counterpart. No mouse β-globin mRNA was detected.

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Authors and Affiliations

  1. Institut für Molekularbiologie I, Universität Zürich, 8093, Zürich, Switzerland

    Ned Mantei, Werner Boll & Charles Weissmann

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  1. Ned Mantei
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  2. Werner Boll
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  3. Charles Weissmann
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Mantei, N., Boll, W. & Weissmann, C. Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA. Nature 281, 40–46 (1979). https://doi.org/10.1038/281040a0

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