Abstract
IN many species of higher organisms there is compensation for the different number of ‘doses’ of X-linked genes in the two sexes. This can be demonstrated by studies on enzymes which show that the level of activity of an X-linked enzyme is the same in the sex with one chromosome as in the sex with two. Dosage compensation therefore represents a system which can be used to study the control of gene activity in eukaryotes. Dosage compensation in Drosophila melanogaster has been extensively reviewed1, and although it has been studied mainly in adult flies it does occur in larval stages2–5 and in cultured cells6. The one published example of an X-linked gene which does not show complete dosage compensation is the white-eosin mutant7 where there is more pigment in the eye of the female homozygote than in the eye of the male hemizygote. Here we report a second example, that of the X-linked α-chain gene of Drosophila larval serum protein-1.
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ROBERTS, D., EVANS-ROBERTS, S. The X-linked α-chain gene of Drosophila LSP-1 does not show dosage compensation. Nature 280, 691–692 (1979). https://doi.org/10.1038/280691a0
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DOI: https://doi.org/10.1038/280691a0
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