Abstract
INTEREST in the biological effects of vanadium has grown particularly since Cantley et al.1 identified vanadate as a potent inhibitor of (Na+ + K+) ATPase and Balfour et al.2 reported its striking natriuretic and diuretic properties in the rat. Such findings prompted us to investigate the effects of vanadate on amphibian epithelia, a model widely used for studying, in vitro, the membrane transport of sodium and water3,4. We found a ouabain-like action of metavanadate on active sodium transport. In addition, we report here a new biological effect of this compound on living cells: the inhibition of cyclic AMP-induced stimulation of transepithelial water flow.
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References
Cantley, L. C. Jr et al. J. biol. Chem. 252, 7421–7423 (1977).
Balfour, W. E., Grantham, J. J. & Glynn, I. M. Nature 275, 768 (1978).
De Sousa, R. C. J. Physiol., Lond. 71, 5A–71A (1975).
Leaf, A. Rev. Physiol. 56, 215–263 (1965).
Li, J. H. & De Sousa, R. C. J. Membrane Biol. 46, 155–169 (1979).
De Sousa, R. C. & Grosso, A. J. Membrane Biol. 40, 77–94 (1978).
Flier, J. S. Nature 274, 285–286 (1978).
Cantley, L. C. Jr, Resh, M. D. & Guidotti, G. Nature 272, 552–554 (1978).
Rüphi, M., De Sousa, R. C., Favrod-Coune, E. & Posternak, J. M. 28, 1391–1393 (1972).
Grosso, A. & De Sousa, R. C. J. Membrane Biol. 40, Suppl. 305–321 (1978).
Hackbarth, I. et al. Nature 275, 67 (1978).
Josephson, L. & Cantley, L. C. Jr Biochemistry 16, 4572–4578 (1977).
Beaugé, L. A. & Glynn, I. M. Nature 272, 551–552 (1978).
Cantley, L. C. Jr, Cantley, L. G. & Josephson, L. J. biol. Chem. 253, 7361–7368 (1978).
Schwabe, U., Puchstein, C., Hannemann, H. & Söchtig, E. Nature 277, 143–145 (1979).
Mills, J. W. & Malick, L. E. J. Cell Biol. 77, 598–610 (1978).
Taylor, A., Mamelak, M., Reaven, E. & Maffly, R. Science 181, 347–349 (1973).
De Sousa, R. C., Grosso, A. & Rufener, C. Experientia 30, 175–177 (1974).
Grosso, A., Spinelli, F. & De Sousa, R. C. Cell Tissue Res. 188, 375–388 (1978).
Kobayashi, T., Martensen, T., Nath, J. & Flavin, M. Biochem. biophys. Res. Commun. 81, 1313–1318 (1978).
Gibbons, I. R. et al. Proc. natn. Acad. Sci. U.S.A. 75, 2220–2224 (1978).
Cande, W. Z. & Wolniak, S. M. J. Cell Biol. 79, 573–580 (1978).
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DE SOUSA, R., GROSSO, A. Vanadate blocks cyclic AMP-induced Stimulation of sodium and water transport in amphibian epithelia. Nature 279, 803–804 (1979). https://doi.org/10.1038/279803a0
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DOI: https://doi.org/10.1038/279803a0
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