Abstract
Cloned segments of mouse chromosomal DNA provide direct evidence for the somatic rearrangement of κ variable and constant region genes in antibody producing cells. This rearrangement apparently affects only one member of an allelic pair of light chain genes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dreyer, W. J. & Bennett, J. C. Proc. natn. Acad. Sci. U.S.A. 54, 864–868 (1965).
Tonegawa, S., Hozumi, N., Matthyssens, G. & Schuller, R. Cold Spring Harb. Symp. quant. Biol. 41, 877–889 (1976).
Tonegawa, S., Brack, C., Hozumi, N. & Schuller, R. Proc. natn. Acad. Sci. U.S.A. 8, 3518–3522 (1977).
Seidman, J. G. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3881–3885 (1978).
Hozumi, N. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 73, 3628–3632 (1976).
Tonegawa, S., Brack, C., Hozumi, N. & Pirrotta, V. Cold Spring Harb. Symp. quant. Biol. 42, 921–931 (1977).
Rabbitts, T. H. & Forster, A. Cell 13, 319–327 (1978).
Tonegawa, S., Maxam, A. M., Tizard, R., Bernard, O. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 75, 1485–1489 (1978).
Brack, C., Hirama, M., Lenhard-Schuller, R. & Tonegawa, S. Cell 15, 1–14 (1978).
Kabat, E. A., Wu, T. T. & Bilofsky, H. Proc. natn. Acad. Sci. U.S.A. 75, 2429–2433 (1978).
Seidman, J. G., Leder, A., Nau, M., Norman, B., & Leder, P. Science 202, 11–17 (1978).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Tilghman, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 10, 4406–4410 (1977).
Tiemeier, D. C. et al. Cell 14, 1309–1313 (1978).
Leder, A. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Blattner, F. R. et al. Science 196, 161–169 (1977).
Bek, A. & Gould, M. Proc. natn. Acad. Sci. U.S.A. 72, 581–585 (1975).
Sternberg, N., Tiemeier, D. & Enquist, L. W. Gene 1, 255–280 (1977).
Seidman, J. G., Edgell, M. H. & Leder, P. Nature 271, 582–585 (1978).
White, R. L. & Hogness, D. S. Cell 10, 177–192 (1977).
Tilghman, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 75, 725–729 (1978).
Lenhard-Schuller, R. et al. Proc. natn. Acad. Sci. U.S.A. 75, 4709–4713 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seidman, J., Leder, P. The arrangement and rearrangement of antibody genes. Nature 276, 790–795 (1978). https://doi.org/10.1038/276790a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/276790a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
