Abstract
Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in Φ80ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalAr mutation. These results indicate that DNA gyrase is involved in transcription.
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Smith, C., Kubo, M. & Imamoto, F. Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase. Nature 275, 420–423 (1978). https://doi.org/10.1038/275420a0
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DOI: https://doi.org/10.1038/275420a0
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