Abstract
COMPETITIVE inhibitors of the octapeptide hormone angiotensin II (AT), Asp-Arg-Val-Tyr-Val-His-Pro-Phe, have been synthesised by several groups1. These inhibitors, like the hormone, are quickly degraded, and no irreversible or even long-acting specific inhibitors have been available. Paiva et al.2 have attempted to produce such inhibitors using affinity labelling analogues, but with poor results. We report here a specific and irreversible inhibition of the response of rabbit aorta strips to AT by a photolabile analogue of AT.
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ESCHER, E., NGUYEN, T., GUILLEMETTE, G. et al. Specific and irreversible block of the myotropic action of angiotensin II. Nature 275, 145–146 (1978). https://doi.org/10.1038/275145a0
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DOI: https://doi.org/10.1038/275145a0
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