Abstract
FUNCTIONAL roles have been proposed for the purine nucleotides and nucleosides shown to be released by several neural tissues1,2. In the autonomic nervous system, ATP or a related purine compound has been ascribed a transmitter role in the ‘purinergic‘ nerve hypothesis3. Although some metabolites of ATP have been demonstrated in perfusates of field-stimulated gastrointestinal smooth-muscle preparations4, the precise identity of the mediator released from ‘purinergic‘ nerves has not been established, and the existence of such nerves is not widely accepted5. Structure–activity considerations suggested to us that coenzyme A (CoA), a substituted purine nucleotide, should interact with the ‘purinergic’ receptor—to our knowledge there are no reports of such interactions, or of any other autonomic effect of CoA, in the literature. We report here the presynaptic inhibitory effects of CoA and its analogues on acetylcholine release.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McIlwain, H. Biochem. Soc. Symp. 36, 69–85 (1972).
Silinsky, B. M. & Hubbard, J. I. Nature, 243, 404–405 (1973).
Burnstock, G. Pharmac. Rev. 24, 509–580 (1972).
Burnstock, G., Campbell, G., Satchell, D. G. & Smythe, A. Br. J. Pharmac. Chemother. 40, 668–688 (1970).
Daniel, E. E., Taylor, G. S., Daniel, V. P. & Holman, M. E. Can. J. Physiol. Pharmac. 55, 243–250 (1977).
Paton, W. D. M. & Vizi, E. S. Br. J. Pharmac. Chemother. 35, 10–18 (1969).
De Gubareff, R. & Sleator, W. J. Pharmac. exp. Therap. 148, 202–214 (1965).
Afonso, S. Circulation Res. 26, 743–752 (1970).
Okwuasaba, F. K., Hamilton, J. T. & Cook, M. A. Eur. J. Pharmac. 43, 181–194 (1977).
Arunlakshana, O. & Schild, H. O. Br. J. Pharmac. Chemother. 14, 45–58 (1959).
Stafford, A. Br. J. Pharmac. Chemother. 28, 218–227 (1966).
Satchell, D. G., Lynch, A., Bourke, P. & Burnstock, G. Eur. J. Pharmac. 19, 343–350 (1972).
Satchell, D. G. & Burnstock, G. Eur. J. Pharmac. 32, 324–328 (1975).
Pfleger, K. & Schondörf, H. Arzniem. Forsch. 19, 97–98 (1969).
Vizi, E. S. & Knoll, J. J. Pharm. Pharmac. 23, 918–925 (1971).
Whittaker, V. P., Dowdall, M. J. & Boyne, A. F. Biochem. Soc. Symp. 36, 49–68 (1972).
Kaplan, N. O. & Lipman, F. J. Biochem. 174, 37–44 (1948).
White, H. L. & Cavallito, C. J. Biochem. biophys. Acta 206, 343–358 (1970).
White, H. L. & Wu, J. C. J. Neurochem. 20, 297–307 (1973).
Haubrich, D. R. & Chippendale, T. J. Life Sci. 20, 1465–1478 (1977).
Beani, L., Bianchi, C. & Crema, A. J. Physiol., Lond. 217, 259–279 (1971).
Wonnacott, T. H. & Wonnacott, R. J. (eds) Analysis of Variance in Introductory Statistics for Business and Economics (Wiley, New York. 1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COOK, M., HAMILTON, J. & OKWUASABA, F. Coenzyme A is a purine nucleotide modulator of acetylcholine output. Nature 271, 768–771 (1978). https://doi.org/10.1038/271768a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/271768a0
This article is cited by
-
Protective action of panthetin on the denervated stomach
Bulletin of Experimental Biology and Medicine (1987)
-
Relationship of metabolism of 2?-, 3?- and 5?-adenine nucleotides to presynaptic inhibition of transmitter release in rat vas deferens
Naunyn-Schmiedeberg's Archives of Pharmacology (1986)
-
Coenzyme A or adenosine inhibiting acetylcholine release?
Nature (1978)
-
Coenzyme A or adenosine inhibiting acetylcholine release? (reply)
Nature (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
