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Directed outgrowth of optic fibres regenerating in vitro

Nature volume 271, pages 360–362 (1978)Cite this article

Abstract

THE way in which growing nerve fibres find their destined sites of termination is largely unknown, although there are supporting arguments and documentation for both local and long-range guidance mechanisms1–3. Fibres regenerating following axotomy tend to grow in the direction of the degenerating tracts, apparently guided through channels formed by debris and/or glial cells4,5. Here we present evidence that the neuritic outgrowth from goldfish retinal explants is related to the orientation of cut fibres within the explant.

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Author notes

  1. MYONG G. YOON

    Present address: Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada

Authors and Affiliations

  1. Neuroscience Laboratory, University of Michigan, Ann Arbor, Michigan, 48109

    PAMELA RAYMOND JOHNS, MYONG G. YOON & BERNARD W. AGRANOFF

Authors
  1. PAMELA RAYMOND JOHNS
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  2. MYONG G. YOON
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  3. BERNARD W. AGRANOFF
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JOHNS, P., YOON, M. & AGRANOFF, B. Directed outgrowth of optic fibres regenerating in vitro. Nature 271, 360–362 (1978). https://doi.org/10.1038/271360a0

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