Abstract
THE principal neurones of the vertebrate sympathetic ganglia usually respond to suitable preganglionic stimuli with three types of temporally distinguishable postsynaptic potential (PSPs) in the following sequence: an initial excitatory one (fast EPSP), a slow inhibitory one (slow IPSP) and a slow excitatory one (slow EPSP)1,2. These three responses can also be distinguished pharmacologically: the fast EPSP is mediated by a nicotinic acetylcholine receptor, and the slow EPSP by a muscarinic acetylcholine receptor. The synaptic pathway of the slow IPSP includes intervening adrenergic cells (called “SIF” cells3) which release a catecholamine transmitter (identified as dopamine in the case of rabbbit4,5), in response to the muscarinic action of acetylcholine, and in turn hyperpolarise the ganglion cells.
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KOBAYASHI, H., HASHIGUCHI, T. & USHIYAMA, N. Postsynaptic modulation of excitatory process in sympathetic ganglia by cyclic AMP. Nature 271, 268–270 (1978). https://doi.org/10.1038/271268a0
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DOI: https://doi.org/10.1038/271268a0
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