Abstract
METHYLCHOLANTHRENE-induced sarcomas of mice (MCS) usually have transplantation antigens specific to each independently arising tumour1. These antigens, defined by in vivo protection assays, are different from those defined serologically as viral2 or embryonic antigens3,4. The latter, common to most sarcomas, seem to contribute little in transplantation assays as cross protection is rare and weak1,5. The occasional success in protecting against sarcoma growth by previous immunisation with cells of mid-term embryos4,6 encourages the search for more effective ways of using common embryonic antigens for this purpose. We show here that effective immunisation against several different non-cross-reacting sarcomas, including one not immunogenic itself, can be achieved with embryonal carcinoma cells. These cells are the stem cells of a teratocarcinoma and show remarkable similarities to the pluripotent cells of early mouse embryos with regard to cell surface antigens7 as well as in morphological and biochemical properties8.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Basombrio, M. A. Cancer Res. 30, 2458–2462 (1970).
Grant, J. D., Bigner, D. B., Fischinger, P. J. & Bolognesi, D. P. Proc. natn. Acad. Sci. U.S.A. 71, 5037–5041 (1974).
Brawn, R. J. Int. J. Cancer 6, 245–249 (1970).
Baldwin, R. W., Embleton, M. J., Price, M. R. & Vose, B. M. Transplant. Rev. 20, 77–99 (1974).
Reiner, J. & Southam, C. M. Cancer Res. 27, 1243–1247 (1967).
Coggin, J. H. & Anderson, N. G. Adv. Cancer Res. 19, 105–165 (1974).
Erickson, R. P. in Immunobiology of Gametes (eds Johnson, M. & Edidin. M.) 85–114 (Cambridge University Press, Cambridge, 1977).
Martin, G. R. Cell 5, 229–243 (1975).
Bartlett, G. L. J. natn. Cancer Inst. 49, 493–504 (1972).
Martin, G. R. & Evans, M. J. in Teratomas and Differentiation (eds Sherman. M. I. & Solter, D.) 169–187 (Academic, London. 1975).
Gorer, P. A. & Amos, D. B. Cancer Res. 16, 338–343 (1956).
Dunn, T. B. & Potter, M. J. natn. Cancer Inst. 18, 587–595 (1957).
Evans, M. J., Lovell-Badge, R., & Stern, P. L. in European Teratology Soc. Meet. Symp. (in the Press).
Lehman, J. M., Speers, W. C., Swartzendruber, P. E. & Pierce, G. B. J. Cell Physiol. 84, 13–28 (1974).
Smith, S. E. & Scott, M. T. Br. J. Cancer 26, 361–367 (1972).
Gooding, L. R. & Edidin, M. J. exp. Med. 140, 61–78 (1974).
Gooding, L. R., Hsu, Y. C. & Edidin, M. Devl Biol. 49, 479–486 (1976).
Bartlett, P. F., Fenderson, B. A. & Edidin, M. Fedn Proc. 36, 1290 (1977).
Artzt, K. & Jacob, E. Transplantation 17, 632–634 (1974).
Doherty, P. C., Blanden, R. V. & Zinkernagel, R. M. Transplant. Rev. 29, 89–124 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SIKORA, K., STERN, P. & LENNOX, E. Immunoprotection by embryonal carcinoma cells for methyl-cholanthrene-induced murine sarcomas. Nature 269, 813–815 (1977). https://doi.org/10.1038/269813a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/269813a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
