Abstract
Keratinocytes of three different epithelia grown in cell culture express a large number of differentiation markers with either no differences or relatively small differences, depending on the species. Much of the distinctive phenotype of these epithelia in vivo must be due to external modulation and relatively little, at least in the case of the human, to permanent intrinsic divergence during development.
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References
Rheinwald, J. G. & Green, H. Cell 6, 331–344 (1975).
Rheinwald, J. G. & Green, H. Nature 265, 421–424 (1977).
Sun, T.-T. & Green, H. Cell 9, 511–521 (1976).
Rice, R. H. & Green, H. Cell 11, 417–422 (1977).
Green, H. Cell 11, 405–415 (1977).
Allman, M. I. et al. Invest. Ophthal. 15, 666–668 (1976).
Newsome, D. A., Takasugi, M., Kenyon, K. R., Start, W. F. & Opelz, G. Invest. Ophthal. 13, 23–32 (1974).
Yanoff, M. Documenta ophth. 41, 157–204 (1976).
Cohen, S., Carpenter, G. & Lembach, K. J. in Advances in Metabolic Disorders, 8 (ed. Lust, R. & Hall, K.) 265–284 (Academic, New York, 1975).
Savage, C. F., Jr & Cohen, S. Expl Eye Res. 15, 361–366 (1973).
Steinert, P. M. Biochem. J. 149, 39–48 (1975).
Baden, H. P., Lee, L. D. Kubilus, J. J. invest. Derm. 67, 573–576 (1976).
Yardley, H. J. & Goldstein, D. J. Br. J. Derm. 95, 621–626 (1976).
Billingham, R. E. & Silvers, W. K. J. exp. Med. 125, 429–446 (1967).
Sengel, P. Marphogenesis of Skin (Cambridge University Press, Cambridge, 1976).
Van Scott, E. J. & Reinertson, R. P. J. invest. Derm. 36, 109–131 (1961).
Goldberg, B. Cell 11, 169–172 (1977).
Todaro, G. J. & Green, H. J. Cell Biol. 17, 299–313 (1963).
Rheinwald, J. G. & Green, H. Cell 6, 317–330 (1975).
Yen, S.-H., Dahl, D., Schachner, M. & Shelanski, M. L. Proc. natn. Acad. Sci. U.S.A. 73, 529–533 (1976).
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Sun, TT., Green, H. Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states. Nature 269, 489–493 (1977). https://doi.org/10.1038/269489a0
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DOI: https://doi.org/10.1038/269489a0
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