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Structure of a dinucleoside phosphate–drug complex as model for nucleic acid–drug interaction

Nature volume 269, pages 304–307 (1977)Cite this article

Abstract

The crystal structure of a 3 : 2 complex of the frameshift mutagen proflavine with the dinucleoside phosphate cytidylyl-3′5′-guanosine has been determined. The complex has one drug molecule intercalated between Watson–Crick base pairs of the nucleotide duplex. The other two proflavine molecules are bound to the exterior of the miniature double helix. The orientation of the base pairs in this miniature double helix has aspects similar to that found in RNA 11.

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Authors and Affiliations

  1. Department of Biophysics, University of London King's College, 26–29 Drury Lane, London, WC2, UK

    S. Neidle, A. Achari & G. L. Taylor

  2. The Institute for Cancer Research, 7701 Burholme Avenue, Fox Chase, Philadelphia, Pennsylvania, 19111

    Helen M. Berman, H. L. Carrell, J. P. Glusker & W. C. Stallings

Authors
  1. S. Neidle
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  2. A. Achari
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  3. G. L. Taylor
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  4. Helen M. Berman
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  5. H. L. Carrell
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  6. J. P. Glusker
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  7. W. C. Stallings
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Neidle, S., Achari, A., Taylor, G. et al. Structure of a dinucleoside phosphate–drug complex as model for nucleic acid–drug interaction. Nature 269, 304–307 (1977). https://doi.org/10.1038/269304a0

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