Abstract
IT has recently been demonstrated that the undecapeptide substance P (SP) produces analgesia in mice when administered intracerebroventricularly (i.v.) or intraperitoneally (i.p.)1. This effect of SP was reversed by naloxone indicating the possible involvement of central opiate receptors. The possibility that SP may act on opiate receptors at the single neurone level has been investigated on spinal Renshaw cells in the cat. These cells possess stereo-specific opiate receptor sites2,3. The results obtained show that SP excites Renshaw cells and that this action is antagonised by naloxone. Substance P also reduced the excitation of Renshaw cells by acetylcholine.
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DAVIES, J., DRAY, A. Substance P and opiate receptors. Nature 268, 351–352 (1977). https://doi.org/10.1038/268351a0
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DOI: https://doi.org/10.1038/268351a0
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