Abstract
PROSTACYCLIN (prostaglandin X, PGI2), a newly discovered prostaglandin1–3, is formed by microsomes from several organs, such as pig and rabbit aorta2 and rat stomach4, and by fresh human arterial and venous tissue incubated with PGH2 (ref. 5). As inhibitor of blood platelet aggregation, it is 30 times more potent than PGE1 (ref. 2) and could thus help in preventing the formation of intra-arterial thrombi. It has been suggested1 that the endoperoxides released by the platelets can be converted into prostacyclin by vascular tissue. Prostacyclin is chemically unstable in aqueous solution: it hydrolyses to 6-oxo-PGF1α (refs 3, 4; Fig. 1) which does not inhibit platelet aggregation2. We report that isolated perfused rabbit and rat hearts produce a labile factor which strongly inhibits blood platelet aggregation; the release of this substance is abolished by indomethacin. Using a physicochemical method, we found 6-oxo-PGF1α in substantial amounts in the perfusates. These findings indicate that prostacyclin is the major prostaglandin released from the heart.
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DE DECKERE, E., NUGTEREN, D. & TEN HOOR, F. Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart. Nature 268, 160–163 (1977). https://doi.org/10.1038/268160a0
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DOI: https://doi.org/10.1038/268160a0
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