Abstract
STABLE mutations affecting mitochondrial functions have been reported in lower eukaryotes1–7 and higher organisms8–11. We have described a procedure to select mutants with defective patterns of oxidative energy metabolism from established Chinese hamster fibroblasts8, which seem to satisfy most of their energy needs from glycolysis6. We describe here a mutant which has properties reminiscent of the petite phenotype of yeast ρ− mutants5,13,14: a defect in mitochondrial protein synthesis leads to multiple enzymatic deficiencies.
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DITTA, G., SODERBERG, K. & SCHEFFLER, I. Chinese hamster cell mutant with defective mitochondrial protein synthesis. Nature 268, 64–67 (1977). https://doi.org/10.1038/268064a0
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DOI: https://doi.org/10.1038/268064a0
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