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Hydroxyproline-containing protein adsorbed on to cellular elements of whole human blood

Nature volume 267, pages 272–274 (1977)Cite this article

Abstract

CURRENT hypotheses suggest that blood clotting occurs when, as a primary event, platelets come into direct contact with collagenous fibrils which have been exposed in vessel walls. We report here that a collagen component is normally associated with the cellular elements of blood. It was demonstrated by analysing whole blood and its fractions for protein-bound hydroxyproline, and shown by immunofluorescence in clotted blood smears using a specific antiserum to human collagen. As a blood component it is distinct from and additional to C1q, the hydroxyproline-containing protein which is a part of the first component of complement.

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Authors and Affiliations

  1. Stetler Fellow, Department of Pathology, College of Medicine,

    ROBIN MILLER

  2. Department of Histology, College of Dentistry, University of Illinois at the Medical Center, Chicago, Illinois, 60612

    M. B. ENGEL & H. R. CATCHPOLE

Authors
  1. ROBIN MILLER
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  2. M. B. ENGEL
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  3. H. R. CATCHPOLE
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MILLER, R., ENGEL, M. & CATCHPOLE, H. Hydroxyproline-containing protein adsorbed on to cellular elements of whole human blood. Nature 267, 272–274 (1977). https://doi.org/10.1038/267272a0

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