Abstract
PATHOGENICITY of viruses is commonly related to their ability to multiply within the host's cells. Although, in certain conditions, the inoculation of large doses of uninfectious virus can produce a fatal disease1, the toxicity of viral components as such for laboratory animals has never been demonstrated. We have shown that although frog virus 3 (FV 3) is unable to multiply in mice, it produces an acute degenerative hepatitis leading to the death of the animals in less than 24 h (refs 2, 3). We report here that solubilised viral proteins also produce this hepatotoxic effect.
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References
Henle, G. & Henle, W. J. exp. med., 84, 623–637 (1946).
Bingen-Brendel, A. et al., Annls Inst. Pasteur, Paris, 122, 125–142 (1972).
Elharrar, M., Bingen, A., Gendrault, J. L., and Kirn, A., in Pathogenesis and Mechanisms of Liver Cell Necrosis (edit. by Keppler, D.,) 75–86 (Medical and Technical, Lancaster, 1975).
Aubertin, A-M., Travo, C., and Kirn, A., J. Virol., 18, 34–41 (1976).
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AUBERTIN, AM., ANTON, M., BINGEN, A. et al. Solubilised viral proteins produce fatal hepatitis in mice. Nature 265, 456–457 (1977). https://doi.org/10.1038/265456a0
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DOI: https://doi.org/10.1038/265456a0
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