Abstract
EREZ et al.1 have classified chloropractolol as an irreversible, covalently-binding, antagonist of cardiac β adrenoceptors. This conclusion was based on the knowledge that similar halogen amides can alkylate sulphydryl groups2,3 and their observation that chloropractolol produced a long-lasting antagonism of β adrenoceptors associated with a depression of the maximum response to isoprenaline.
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KENAKIN, T., BLACK, J. Can chloropractolol alkylate β adrenoceptors?. Nature 265, 365–366 (1977). https://doi.org/10.1038/265365a0
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DOI: https://doi.org/10.1038/265365a0
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