Abstract
OPIATES inhibit basal and prostaglandin E1-stimulated formation of cyclic AMP by homogenates of cultured neuroblastoma × glioma hybrid cells1,2. The opiate inhibition is stereospecific and is blocked by the specific opiate antagonist naloxone. Thus, interaction of an opiate agonist with its receptor inhibits adenylate cyclase activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sharma, S. K., Nirenberg, M., and Klee, W. A., Proc. natn. Acad. Sci. U.S.A., 72, 590–594 (1975).
Traber, J., Fischer, K., Latzin, S., and Hamprecht, B., Nature, 253, 120–122 (1975).
Teschemacher, H., Opheim, K. E., Cox, B. M., and Goldstein, A., Life. Sci., 16, 1771–1776 (1975).
Cox, B. M., Opheim, K. E., Teschemacher, H., and Goldstein, A., Life. Sci., 16, 1777–1782 (1975).
Cox, B. M., Gentleman, S., Su-T.-P., and Goldstein, A., Brain Res, 115, 285 (1976).
Cox, B. M., Goldstein, A., and Li, C. H., Proc. natn. Acad. Sci. U.S.A., 73, 1821–1823 (1976).
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., and Morris, H. R., Nature 258, 577–579 (1975).
Goldstein, A., Science, 193, 1081–1086 (1976).
Gentleman, S., Ross, M., Lowney, L. I., Cox, B. M., and Goldstein, A., in Opiates and Endogenous Opioid Peptides (North-Holland, Amsterdam, 1976).
Bradbury, A. F., Smyth, D. G., Snell, C. R., Birdsall, N. J. M., and Hulme, E. C., Nature, 260, 793–795 (1976).
Feldberg, W. S., and Smyth, D. G., J. Physiol., Lond., 206, 30–31 (1976).
Kosterlitz, H. W., Lydon, R. J., and Watt, A. J., Br. J. Pharmac., 39, 398–413 (1970).
Kosterlitz, H. W., and Watt, A. J., Br. J. Pharmac., 33, 266–276 (1968).
Ross, M., Su, T.-P., Cox, B. M., and Goldstein, A., in Opiates and Endogenous Opioid Peptides (North-Holland, Amsterdam, 1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOLDSTEIN, A., COX, B., KLEE, W. et al. Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells. Nature 265, 362–363 (1977). https://doi.org/10.1038/265362a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/265362a0
This article is cited by
-
Effects of N-LAAM on [3H]etorphine binding in neuronal-enriched cell cultures
Neurochemical Research (1983)
-
Effect of met-enkephalin and (d-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain
Neurochemical Research (1979)
-
Psychotropic properties of some hypophysis peptide hormones (literature review)
Pharmaceutical Chemistry Journal (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
