Abstract
HUMAN plasma high density lipoproteins (HDL) seem to have a protective effect against the development of atherosclerosis1,2. Glomset proposed that unesterified cholesterol diffuses from cell membranes into the HDL particle following esterification of cholesterol in HDL by the action of plasma lecithin: cholesterol acyltransferase3. In tissue culture experiments, HDL4 and complexes of its apoproteins with phospholipids5 removed cholesterol from arterial smooth muscle cells, and the principal HDL apoprotein, apo-A1, adsorbed to and removed phospholipid from Land-schutz ascites cells6. We show that intact HDL releases part of its apoprotein when incubated with synthetic phospholipid membranes, leading to the formation of soluble, discoidal phospholipid–apoprotein complexes. The residual apoprotein-deficient HDL particles seem to undergo fusion.
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TALL, A., SMALL, D. Solubilisation of phospholipid membranes by human plasma high density lipoproteins. Nature 265, 163–164 (1977). https://doi.org/10.1038/265163a0
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DOI: https://doi.org/10.1038/265163a0
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