Abstract
ALTHOUGH abnormal lung tissue, especially certain bronchogenie tumours, may secrete a variety of peptide hormones1, none has been isolated from normal lung. We have now extracted from normal hog lungs peptide fractions containing at least two active principles, one of which relaxes and the other contracts non-vascular smooth-muscle organs. Like the recently isolated vasoactive intestinal peptide (VIP)2, both pulmonary peptide fractions are systemic vasodilators. The relaxant peptide fraction further resembles VIP in its smooth-muscle effects, and binds with antibodies against this peptide. The spasmogenic peptide fraction contracts a variety of smooth-muscle organs that are also contracted by prostaglandins, bradykinin, angiotensin II, substance P, and the “slow-reacting substance of anaphylaxis”. Immunoreactivity attributable to the relaxant, VIP-like peptide, was found in normal lungs of several mammals, including man, and in pulmonary oedema foam.
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SAID, S., MUTT, V. Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive compounds. Nature 265, 84–86 (1977). https://doi.org/10.1038/265084a0
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DOI: https://doi.org/10.1038/265084a0
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