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Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

Nature volume 264, pages 722–727 (1976)Cite this article

Abstract

The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.

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Authors and Affiliations

  1. Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois, 60612

    Noël Bouck & Giampiero di Mayorca

Authors
  1. Noël Bouck
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  2. Giampiero di Mayorca
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Bouck, N., di Mayorca, G. Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens. Nature 264, 722–727 (1976). https://doi.org/10.1038/264722a0

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