Abstract
THE adhesion of platelets to collagen in the subendothelial tissue is generally considered to be the primary step in haemostasis following vascular injury. The biochemical basis of this interaction is not fully understood but it has been suggested by Jamieson and coworkers1,2 that the adhesion of platelets to collagen is mediated by the formation of an enzyme–acceptor complex between a glucosyltransferase on the platelet membrane and incomplete carbohydrate residues present in collagen. We report here studies confirming the presence of collagen glucosyltransferase activity associated with platelets but investigations of the influence of collagen substrate conformation on enzyme activity suggest that the above hypothesis is probably untenable.
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MENASHI, S., HARWOOD, R. & GRANT, M. Native collagen is not a substrate for the collagen glucosyltransferase of platelets. Nature 264, 670–672 (1976). https://doi.org/10.1038/264670a0
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DOI: https://doi.org/10.1038/264670a0
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