Abstract
THE activity of tyrosine hydroxylase (TH), the enzyme catalysing the initial and presumed rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (DA) and noradrenaline (NA), varies over a twofold range in the brains of different strains of inbred mice1. The molecular mechanisms responsible for these strain-dependent differences in enzyme activity remain to be established1,2.
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ROSS, R., JUDD, A., PICKEL, V. et al. Strain-dependent variations in number of midbrain dopaminergic neurones. Nature 264, 654–656 (1976). https://doi.org/10.1038/264654a0
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DOI: https://doi.org/10.1038/264654a0
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